Senior Scientist, Ionizable Lipids & LNP Formulations

Pioneering Medicines; Cambridge (MA); On-site; USD 126,000 - 182,000; Full time

Benefits offered by this job

Competitive compensation and benefits

Career development and mentorship

Frontier science environment

Job summary

Serif Biomedicines is seeking a Senior Scientist II with deep lipid chemistry expertise to drive the design of novel ionizable lipids and next-gen LNP formulations for nucleic acid delivery. The role focuses on SAR-driven design, optimized LNP molar compositions, and preparation of scalable formulations for screening.

This senior scientist will operate with independence, guide cross-functional programs, mentor junior scientists, and contribute to the broader scientific strategy and IP for the

Qualifications

• PhD or MS with relevant industry experience in organic synthesis and lipid delivery materials.
• Experience with lipid nanoparticles (LNPs) and formulation science.
• Proven ability to design and optimize ionizable lipids and LNP compositions.
• Experience characterizing lipids and formulations (NMR, LC-MS, CAD/ELSD, DLS).
• Experience in nucleic acid delivery (mRNA, DNA, siRNA).
• Strong collaboration and mentoring skills.

Responsibilities

• Design and synthesize ionizable lipids with SAR and pKa profiling guidance.
• Lead LNP molar composition design for potency and tolerability.
• Prepare LNP formulations for screening at multiple scales.
• Plan formulation screens and build structure–property relationships.
• Characterize lipids and LNPs and confirm identity/purity.
• Collaborate with biology/analytical teams to test lead formulations.
• Analyze data and communicate findings to stakeholders.
• Mentor junior scientists and contribute to strategy and IP.
• Stay current with ionizable lipid chemistry and LNP tech.

Skills

Lipid chemistry

LNP formulation

Nucleic acid delivery

Structure-activity design

Experiment design

Communication & collaboration

Mentoring

Education

PhD in Organic/Medicinal/Chemical Biology or related (or MS with 8+ years)

Tools

NMR

LC-MS

HPLC-CAD/ELSD

DLS

Job description

Serif Biomedicines is seeking a Senior Scientist II with deep lipid chemistry expertise to drive the design of novel ionizable lipids and next-gen LNP formulations for nucleic acid delivery. The role focuses on SAR-driven design, optimized LNP molar compositions, and preparation of scalable formulations for screening.

This senior scientist will operate with independence, guide cross-functional programs, mentor junior scientists, and contribute to the broader scientific strategy and IP for the