Senior Scientist, Hematology: Target Discovery

Novartis AG; Cambridge (MA); On-site; USD 94,000 - 183,000; Full time

Job summary

Novartis AG in Cambridge, MA is seeking a highly motivated laboratory scientist for the Target Biology and Discovery group. You will work on identifying and validating novel therapeutic targets in hematologic cancers, with a focus on myeloid malignancies, using CRISPR, molecular biology, and disease models.

The role combines hands-on experimental work with data integration to shape project strategy and investment decisions.

Qualifications

• Bachelor’s or Master’s degree in biology or related field with 3–5 years lab experience.
• Hands-on molecular and cellular biology experience.
• Experience developing robust, reproducible cellular assays.
• Proficiency in mammalian cell culture and molecular/protein-analysis methods (cloning, qPCR, Western blot, flow cytometry).
• Ability to translate scientific questions into well‑controlled experimental plans and communicate conclusions.

Responsibilities

• Identify critical drug‑discovery questions and develop experimental strategies.
• Support target identification and validation in hematologic malignancies (AML/MDS) using CRISPR perturbation and gene modulation.
• Develop and optimize cellular assays for early therapeutic development; apply techniques like western blotting, qPCR, imaging, and phenotyping.
• Establish disease-relevant hematologic models including patient-derived samples and cancer cell lines.
• Collaborate in a matrixed environment to develop project strategy and communicate results.

Skills

Analytical Thinking

Chemical Biology

Chemistry

Clinical Research

Data Analysis

Design of Experiments

Mammalian Cell Culture

Immunology

Gene Therapy

Education

Bachelor’s or Master’s in Biology/Related Field

Tools

CRISPR-based perturbation

qPCR

Western Blot

Flow Cytometry

Cellular Assays

Job description

Novartis AG in Cambridge, MA is seeking a highly motivated laboratory scientist for the Target Biology and Discovery group. You will work on identifying and validating novel therapeutic targets in hematologic cancers, with a focus on myeloid malignancies, using CRISPR, molecular biology, and disease models.

The role combines hands-on experimental work with data integration to shape project strategy and investment decisions.