Senior Principal Scientist, Immune Engager Discovery

Novartis Group Companies; Cambridge (MA); On-site; USD 132,000 - 246,000; Full time

Job summary

Novartis Group of Companies in Cambridge, MA, seeks a highly collaborative scientist to lead biology and drug-discovery efforts for immune engagers and multispecific immune modulators. The role combines cancer-immunology expertise with rigorous decision making and cross-functional leadership to advance programs from target validation toward clinical development.

The candidate will design mechanistic studies, supervise scientists, and contribute to strategy prioritization within an experienced

Qualifications

• PhD in cancer biology or immunology with 5+ years of experience or MS with 10+ years.
• Strong expertise in cancer biology or immunology, especially T cell or myeloid biology.
• Experience with immune-engager discovery in cross-functional teams.
• Ability to translate complex data into project decisions and publish findings.
• Excellent communication and collaboration skills.

Responsibilities

• Identify and validate tumor-targeting strategies for immune engagers.
• Lead biology strategy and execution for multidisciplinary drug-discovery programs.
• Serve as project team leader, integrating engineering, translational, and safety Perspectives.
• Design mechanistic studies of immune activation, anti-tumor activity, and safety biology.
• Present evidence-based recommendations and development plans at governance reviews.
• Supervise scientists and build internal/external collaborations.
• Contribute to immune-engager strategy and next-generation modality innovation.

Skills

Cancer biology

Immunology

T cell biology

Myeloid cell biology

Flow cytometry

Immunophenotyping

Translational biology

Data interpretation

Project leadership

Communication

Education

PhD in cancer biology or immunology

MS in a related field

Tools

Flow cytometry

Antibody engineering

Biologics discovery

Data analysis software

Job description

Novartis Group of Companies in Cambridge, MA, seeks a highly collaborative scientist to lead biology and drug-discovery efforts for immune engagers and multispecific immune modulators. The role combines cancer-immunology expertise with rigorous decision making and cross-functional leadership to advance programs from target validation toward clinical development.

The candidate will design mechanistic studies, supervise scientists, and contribute to strategy prioritization within an experienced