Senior Scientist I/II, Hematology- Target Biology and Discovery

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); Sur place; USD 94 000 - 174 000; Plein temps

Résumé du poste

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA is seeking a laboratory scientist to join the Target Biology and Discovery group. You will identify critical drug‑discovery questions, validate targets in hematologic malignancies, and develop cellular assays to advance early drug discovery.

You will work with disease‑relevant models, including patient‑derived samples and cell lines, collaborating across teams to shape project strategy and deliver insights for decision making.

Qualifications

• Bachelor’s or master’s degree in biology, cellular or molecular biology, or a related scientific discipline.
• Hands‑on experience designing, executing, and interpreting molecular and cellular biology experiments.
• Experience developing robust, reproducible cellular assays.
• Strong proficiency in mammalian cell culture and molecular and protein‑analysis methods such as cloning, qPCR, western blotting, and multiparameter flow cytometry.

Responsabilités

• Identify critical drug‑discovery questions and independently develop creative experimental strategies.
• Conduct studies supporting target identification, target validation, and mechanism of action in hematologic malignancies (AML/MDS) using molecular and cellular approaches.
• Develop and optimize cellular assays to drive early therapeutic development or perform deep mechanistic studies using techniques such as western blotting, qPCR, imaging, and cellular phenotyping.
• Establish disease‑relevant hematologic models including patient‑derived samples, cancer cell lines, and engineered cellular systems.
• Collaborate in a matrixed, multidisciplinary environment to develop strategy, prioritize hypotheses, and adapt plans as data emerge.
• Analyze and integrate datasets, communicate results, and contribute to team discussions and presentations.

Connaissances

Analytical Thinking

Mammalian Cell Culture

Molecular Biology

Data Analysis

Laboratory Research

Communication

Design of Experiments

Collaboration

Chemistry

Immunology

Formation

Bachelor’s or master’s degree in biology, cellular or molecular biology

Description du poste

Band Level 3 Job Description Summary #LI-OnSite Location: Cambridge

This position is located in Cambridge, MA and does not have the ability to be located remotely. Please only apply if this area is accessible to you.

The Oncology Department at Novartis Biomedical Research is seeking a highly motivated and collaborative laboratory scientist to join our Target Biology and Discovery group in Cambridge, Massachusetts. In this role, you will help identify and validate novel therapeutic targets and advance early drug-discovery programs for hematologic cancers, with a particular focus on myeloid malignancies. You will combine hands‑on molecular and cellular biology with disease‑relevant model systems to answer critical drug‑discovery questions and generate insights that shape project strategy and investment decisions.

Role Description and Key Responsibilities

• Identify critical drug‑discovery questions and independently develop creative experimental strategies.
• Conduct studies supporting novel target identification, target validation, and mechanism of action in hematologic malignancies such as AML/MDS, using molecular and cellular approaches such as CRISPR‑based perturbation, gene knockdown/overexpression, and chemical probes.
• Develop and optimize cellular assays to drive early therapeutic development or perform deep mechanistic studies, applying techniques such as western blotting, qPCR, imaging, and cellular phenotyping as appropriate to the scientific question.
• Establish and use disease‑relevant hematologic models, including primary patient‑derived or healthy hematopoietic samples and tissues, cancer cell lines, and engineered cellular systems.
• Collaborate effectively in a matrixed, multidisciplinary environment to develop project strategy prioritize hypotheses, and adapt plans as data emerge.
• Analyze and integrate datasets, clearly communicate experimental results and recommendations, and actively contribute to project‑team discussions, and departmental presentations.
• Maintain good laboratory practices in laboratory safety, execution, and documentation.

Essential requirements

• Bachelor’s or master’s degree in biology, cellular or molecular biology, or a related scientific discipline, with 3-5 years of relevant laboratory experience.
• Hands‑on experience designing, executing, and interpreting molecular and cellular biology experiments.
• Experience developing robust, reproducible cellular assays.
• Strong proficiency in mammalian cell culture and molecular and protein‑analysis methods, such as cloning, qPCR, western blotting, and multiparameter flow cytometry.
• Independent ability to translate scientific questions into well‑controlled experimental plans, troubleshoot technical challenges, and communicate decision‑enabling conclusions.
• Strong scientific communication, organization, and collaboration skills.
• Flexibility and ability to adapt to changing priorities as well as apply new techniques.

Preferred requirements

• Experience with primary hematopoietic, immune, or patient‑derived samples.
• Experience with CRISPR‑based functional genomics or genome‑editing approaches.
• Experience with medium‑or high‑throughput screening or profiling.
• Previous experience in pharmaceutical, biotechnology, or translational research environments.
• Familiarity with hematologic malignancies, particularly AML or MDS.

Novartis Compensation and Benefit Summary

Role Leveling

The final level and title will be determined by the hiring team based on skills, experience, and capabilities:

The expected salary range at commencement of employment is: Sr Scientist I: $93,800 - $174,200 Sr Scientist II: $98,700 - $183,400

The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically.

Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance‑based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

US‑based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits.

In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e‑mail to [e-mail] call [phone] and let us know the nature of your request and your contact information. Please include the job requisition number in your message. https://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openings Salary Range $93,800.00 - $174,200.00 Skills Desired Analytical Thinking, Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Communication, Curious Mindset, Data Analysis, Data Management, Design of Experiments (DOE), Detail‑Oriented, Diversity and Inclusion (D&I), Drug Discovery Process, Ethics, Gene Therapy, Immunology, Laboratory Research, Leading Project Teams, Life Science, Machine Learning (ML), Mammalian Cell Culture, Medical Research, Molecular Biology {+ 10 more}

Skills Desired

• Analytical Thinking
• Analytical Thinking
• Chemical Biology
• Chemistry
• Clinical Research
• Clinical Trials
• Collaboration
• Communication
• Curious Mindset
• Data Analysis
• Data Management
• Design of Experiments (DOE)
• Detail‑Oriented
• Diversity and Inclusion (D&I)
• Drug Discovery Process
• Ethics
• Gene Therapy
• Immunology
• Laboratory Research
• Leading Project Teams
• Life Science
• Machine Learning (ML)
• Mammalian Cell Culture
• Medical Research
• Molecular Biology {+ 10 more}

Improving the lives of people living with disease takes more than innovative science. It takes a focus on the needs of people and a community committed to meeting them. It takes a team of people like you. Working together. Learning together. Thriving together. Discover how you can join us in changing people’s lives.

In the context of China Cross‑Border Data Transfer (CBDT) policy, if you need to apply for a position in China, please go to the local Recruiting System TaleNov.