Senior Scientist - Hematology Target Biology & Discovery

Novartis Group Companies; Cambridge (MA); On-site; USD 94,000 - 174,000; Full time

Benefits offered by this job

Health benefits

401(k) with company match

Generous time off package

Equity awards eligibility

Job summary

Novartis Group Companies in Cambridge, MA is seeking a laboratory scientist to identify and validate novel therapeutic targets in hematologic cancers, with emphasis on myeloid malignancies. You will apply molecular and cellular biology techniques, including CRISPR perturbation, to advance early drug-discovery programs.

The role involves developing cellular assays, working with disease-relevant models, and collaborating across disciplines to drive project strategy and data-driven decisions.

Qualifications

• Bachelor's or master's degree in biology, cellular or molecular biology, or related field with 3-5 years of lab experience.
• Hands-on experience designing and executing molecular and cellular biology experiments.
• Experience developing robust, reproducible cellular assays.
• Proficiency in mammalian cell culture and molecular/protein-analysis methods (cloning, qPCR, Western blot, flow cytometry).
• Ability to translate questions into well-controlled experimental plans and troubleshoot.
• Strong scientific communication and collaboration skills.
• Ability to adapt to changing priorities and learn new techniques.

Responsibilities

• Identify drug-discovery questions and independently design experiments.
• Support target identification/validation and mechanism of action studies in AML/MDS.
• Develop and optimize cellular assays for early therapeutic development or mechanistic studies.
• Work with hematologic disease models using patient-derived samples, cell lines, and engineered systems.
• Collaborate in a matrixed environment to shape project strategy and hypotheses.
• Analyze data, communicate results, and contribute to team discussions and presentations.
• Maintain good lab practices and documentation.

Skills

Molecular biology

Cell culture

qPCR

Western blotting

Gene knockdown/overexpression

CRISPR-based perturbation

Data analysis

Communication

Experimental design

Education

Bachelor's or Master's in biology/c cellular or molecular biology

Tools

CRISPR-based perturbation tools

Primary hematopoietic samples handling

Job description

Novartis Group Companies in Cambridge, MA is seeking a laboratory scientist to identify and validate novel therapeutic targets in hematologic cancers, with emphasis on myeloid malignancies. You will apply molecular and cellular biology techniques, including CRISPR perturbation, to advance early drug-discovery programs.

The role involves developing cellular assays, working with disease-relevant models, and collaborating across disciplines to drive project strategy and data-driven decisions.