Senior Scientist, Target Biology & Hematology Discovery

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); On-site; USD 94,000 - 174,000; Full time

Job summary

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA is seeking a laboratory scientist to join the Target Biology and Discovery group. You will identify critical drug‑discovery questions, validate targets in hematologic malignancies, and develop cellular assays to advance early drug discovery.

You will work with disease‑relevant models, including patient‑derived samples and cell lines, collaborating across teams to shape project strategy and deliver insights for decision making.

Qualifications

• Bachelor’s or master’s degree in biology, cellular or molecular biology, or a related scientific discipline.
• Hands‑on experience designing, executing, and interpreting molecular and cellular biology experiments.
• Experience developing robust, reproducible cellular assays.
• Strong proficiency in mammalian cell culture and molecular and protein‑analysis methods such as cloning, qPCR, western blotting, and multiparameter flow cytometry.

Responsibilities

• Identify critical drug‑discovery questions and independently develop creative experimental strategies.
• Conduct studies supporting target identification, target validation, and mechanism of action in hematologic malignancies (AML/MDS) using molecular and cellular approaches.
• Develop and optimize cellular assays to drive early therapeutic development or perform deep mechanistic studies using techniques such as western blotting, qPCR, imaging, and cellular phenotyping.
• Establish disease‑relevant hematologic models including patient‑derived samples, cancer cell lines, and engineered cellular systems.
• Collaborate in a matrixed, multidisciplinary environment to develop strategy, prioritize hypotheses, and adapt plans as data emerge.
• Analyze and integrate datasets, communicate results, and contribute to team discussions and presentations.

Skills

Analytical Thinking

Mammalian Cell Culture

Molecular Biology

Data Analysis

Laboratory Research

Communication

Design of Experiments

Collaboration

Chemistry

Immunology

Education

Bachelor’s or master’s degree in biology, cellular or molecular biology

Job description

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA is seeking a laboratory scientist to join the Target Biology and Discovery group. You will identify critical drug‑discovery questions, validate targets in hematologic malignancies, and develop cellular assays to advance early drug discovery.

You will work with disease‑relevant models, including patient‑derived samples and cell lines, collaborating across teams to shape project strategy and deliver insights for decision making.