Senior Scientist, Antibody Discovery & Therapeutics

SystImmune, Inc.; Bothell (WA); On-site; USD 110,000 - 130,000; Full time

Benefits offered by this job

100% paid employee premiums for health

STD

LTD

401(k) plan with 50% company match of

15 PTO days per year

Sick leave

11 paid holidays

Job summary

SystImmune, Inc. in Bothell, WA is seeking a Senior Scientist to lead antibody discovery efforts in the Antibody Discovery Group. You will design and execute discovery campaigns, perform high-throughput sorting, validate antibodies with FACS, ELISA, and BLI, and collaborate with cross-functional teams to advance candidates toward lead optimization.

This role requires a Ph.D. with 5+ years industry experience in immunology or related field, expertise in yeast display, NGS, single-cell analysis,

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field with 5+years of industry experience, including some applicable post doctoral research experience.
• 3-7 years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry.
• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• A proven track record of working with Sony cell sorters or similar instruments is preferred.
• Experience with single-cell analysis platforms (i.e., Beacon) is highly desirable.
• Experience in antibody discovery and development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is a plus.
• Expertise in molecular biology techniques related to yeast display libraries, including preparation, culture and screening is preferred.

Responsibilities

• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Skills

B-cell sorting

Flow cytometry

ELISA

Biolayer Interferometry

Yeast display libraries

Single-cell analysis (Beacon)

Antibody discovery & development

NGS repertoire analysis

Molecular biology for yeast display

Education

Ph.D. in Immunology, Molecular Biology, Biochemistry, or related field

Tools

Sony cell sorters

Bio-layer Interferometry instruments

Beacon single-cell platform

NGS library preparation

Job description

SystImmune, Inc. in Bothell, WA is seeking a Senior Scientist to lead antibody discovery efforts in the Antibody Discovery Group. You will design and execute discovery campaigns, perform high-throughput sorting, validate antibodies with FACS, ELISA, and BLI, and collaborate with cross-functional teams to advance candidates toward lead optimization.

This role requires a Ph.D. with 5+ years industry experience in immunology or related field, expertise in yeast display, NGS, single-cell analysis,