Scientist, Antibody Discovery

SystImmune, Inc.; Bothell (WA); On-site; USD 90,000 - 115,000; Full time

Benefits offered by this job

Premium medical/dental/vision

401(k) with company match

15 days PTO

11 paid holidays

Job summary

SystImmune, Inc. in Bothell, WA and Princeton, NJ is seeking a Scientist to advance antibody discovery campaigns from design to lead candidates, using B-cell sorting, flow cytometry, ELISA and BLI. The role emphasizes cross-functional collaboration, data analysis, and rigorous assay development in a fast-paced biopharma setting.

Ph.D. in a related field with industry experience and proficiency in single-cell analysis are highly valued, with opportunities to contribute to a robust preclinical

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field; 0–2 years in industry.
• 3–7 years hands-on B-cell sorting and screening via flow cytometry, ELISA and BLI.
• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong ELISA assay development and optimization background.
• Preferred: Sony cell sorters or similar instruments.
• Single-cell analysis platforms (Beacon) highly desirable.
• Antibody discovery and development experience is desirable.
• NGS library prep and BCR repertoire analysis is a plus.
• Molecular biology techniques related to yeast display libraries; culture and screening preferred.

Responsibilities

• Design antibody discovery campaigns from immunization to lead delivery.
• Perform high-throughput sorting to isolate B cell populations.
• Design, execute, and analyze FACS experiments to validate antibodies.
• Develop and optimize ELISA, BLI, and flow assays for screening.
• Conduct yeast display library screening and analyze candidates.
• Analyze data and prepare detailed reports for cross-functional teams.
• Collaborate with project teams and contribute to planning and strategy.
• Maintain records, ensure safety compliance, and aid lab organization.

Education

Ph.D. in Immunology, Molecular Biology, Biochemistry, or related field

Tools

Sony cell sorters

Beacon single-cell platform

BLI instrumentation

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials, SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

We are seeking a highly skilled and motivated Scientist to join our Antibody Discovery Group. The successful candidate will play a critical role in advancing our antibody discovery efforts through various techniques, including immunogen design, B-cell sorting, flow cytometry, ELISA, and yeast library screening. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

Responsibilities

• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field with 0-2 years of industry experience.
• 3-7 years of hands‑on experience in B-cell sorting and screening through flow cytometry, ELISA and bio‑layer interferometry.
• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• A proven track record of working with Sony cell sorters or similar instruments is preferred.
• Experience with single-cell analysis platforms (i.e., Beacon) is highly desirable.
• Experience in antibody discovery and development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is a plus.
• Expertise in molecular biology techniques related to yeast display libraries, including preparation, culture and screening is preferred.

Compensation and Benefits

The expected base salary range for this position is $90,000 - $115,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills. While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmune is a leading and well-funded biotech company with a bright future.

SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.