Senior Scientist, Antibody Discovery

SystImmune, Inc.; Bothell (WA); On-site; USD 110,000 - 130,000; Full time

Benefits offered by this job

100% paid employee premiums for health

STD

LTD

401(k) plan with 50% company match of

15 PTO days per year

Sick leave

11 paid holidays

Job summary

SystImmune, Inc. in Bothell, WA is seeking a Senior Scientist to lead antibody discovery efforts in the Antibody Discovery Group. You will design and execute discovery campaigns, perform high-throughput sorting, validate antibodies with FACS, ELISA, and BLI, and collaborate with cross-functional teams to advance candidates toward lead optimization.

This role requires a Ph.D. with 5+ years industry experience in immunology or related field, expertise in yeast display, NGS, single-cell analysis,

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field with 5+years of industry experience, including some applicable post doctoral research experience.
• 3-7 years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry.
• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• A proven track record of working with Sony cell sorters or similar instruments is preferred.
• Experience with single-cell analysis platforms (i.e., Beacon) is highly desirable.
• Experience in antibody discovery and development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is a plus.
• Expertise in molecular biology techniques related to yeast display libraries, including preparation, culture and screening is preferred.

Responsibilities

• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Skills

B-cell sorting

Flow cytometry

ELISA

Biolayer Interferometry

Yeast display libraries

Single-cell analysis (Beacon)

Antibody discovery & development

NGS repertoire analysis

Molecular biology for yeast display

Education

Ph.D. in Immunology, Molecular Biology, Biochemistry, or related field

Tools

Sony cell sorters

Bio-layer Interferometry instruments

Beacon single-cell platform

NGS library preparation

Job description

SystImmune is a leading and well-funded clinical-stage biopharmaceutical company located in Bothell, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs). SystImmune has multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials. SystImmune has a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.

We are seeking a highly skilled and motivated Senior Scientist to join our Antibody Discovery Group. The successful candidate will play a critical role in advancing our antibody discovery efforts through various techniques, including immunogen design, B-cell sorting, flow cytometry, ELISA, and yeast library screening. This position offers an exciting opportunity to work in a dynamic and innovative environment focused on the development of novel therapeutic antibodies.

Responsibilities

• Design and execute antibody discovery campaigns from immunization to lead delivery.
• Perform high throughput sorting to isolate specific B cell populations.
• Design, execute, and analyze FACS experiments to validate and characterize antibodies.
• Develop, optimize, and perform assays (ELISA, BLI, flow cytometry) for antibody screening and specificity testing.
• Conduct yeast display library screening to identify and analyze antibody candidates.
• Analyze experimental data and prepare detailed reports and presentations.
• Work with cross-functional teams and contribute to project planning and strategy.
• Maintain accurate records, ensure safety compliance, and contribute to lab organization.

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field with 5+years of industry experience, including some applicable post doctoral research experience.
• 3-7 years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA and bio-layer interferometry.
• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong background in ELISA assay development and optimization.
• A proven track record of working with Sony cell sorters or similar instruments is preferred.
• Experience with single-cell analysis platforms (i.e., Beacon) is highly desirable.
• Experience in antibody discovery and development is highly desirable.
• Experience in NGS library preparation and BCR repertoire analysis is a plus.
• Expertise in molecular biology techniques related to yeast display libraries, including preparation, culture and screening is preferred.

Compensation and Benefits

The expected base salary range for this position is $110,000 - $130,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills.

While most offers typically fall within the low to mid-point of the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

• 100% paid employee premiums for medical/dental/vision
• STD
• LTD
• 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years
• 15 PTO days per year
• sick leave
• 11 paid holidays

We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmune is an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.