Antibody Discovery Scientist: B-Cell Sorting & Screening

SystImmune, Inc.; Bothell (WA); On-site; USD 90,000 - 115,000; Full time

Benefits offered by this job

Premium medical/dental/vision

401(k) with company match

15 days PTO

11 paid holidays

Job summary

SystImmune, Inc. in Bothell, WA and Princeton, NJ is seeking a Scientist to advance antibody discovery campaigns from design to lead candidates, using B-cell sorting, flow cytometry, ELISA and BLI. The role emphasizes cross-functional collaboration, data analysis, and rigorous assay development in a fast-paced biopharma setting.

Ph.D. in a related field with industry experience and proficiency in single-cell analysis are highly valued, with opportunities to contribute to a robust preclinical

Qualifications

• Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field; 0–2 years in industry.
• 3–7 years hands-on B-cell sorting and screening via flow cytometry, ELISA and BLI.
• Proficiency in flow cytometry and cell sorting techniques.
• Experience in biolayer interferometry (affinity, avidity, binning) or similar assays.
• Strong ELISA assay development and optimization background.
• Preferred: Sony cell sorters or similar instruments.
• Single-cell analysis platforms (Beacon) highly desirable.
• Antibody discovery and development experience is desirable.
• NGS library prep and BCR repertoire analysis is a plus.
• Molecular biology techniques related to yeast display libraries; culture and screening preferred.

Responsibilities

• Design antibody discovery campaigns from immunization to lead delivery.
• Perform high-throughput sorting to isolate B cell populations.
• Design, execute, and analyze FACS experiments to validate antibodies.
• Develop and optimize ELISA, BLI, and flow assays for screening.
• Conduct yeast display library screening and analyze candidates.
• Analyze data and prepare detailed reports for cross-functional teams.
• Collaborate with project teams and contribute to planning and strategy.
• Maintain records, ensure safety compliance, and aid lab organization.

Education

Ph.D. in Immunology, Molecular Biology, Biochemistry, or related field

Tools

Sony cell sorters

Beacon single-cell platform

BLI instrumentation

Job description

SystImmune, Inc. in Bothell, WA and Princeton, NJ is seeking a Scientist to advance antibody discovery campaigns from design to lead candidates, using B-cell sorting, flow cytometry, ELISA and BLI. The role emphasizes cross-functional collaboration, data analysis, and rigorous assay development in a fast-paced biopharma setting.

Ph.D. in a related field with industry experience and proficiency in single-cell analysis are highly valued, with opportunities to contribute to a robust preclinical