Senior Scientist, ADC & Bioconjugate Separations

Abzena

Bristol Township (Bucks County)

On-site

USD 120,000 - 180,000

Full time

20 hours ago

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Job summary

Abzena in the United States is seeking an experienced separations scientist to develop methods for conjugate characterization supporting ADCs, oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities. This role will serve as a technical expert in separations-based characterization and method development across process development and CMC activities.

You will lead chromatographic workflows for structural characterization, impurity analysis, DAR determination, and

Qualifications

PhD in Analytical Chemistry or related field with 5–8 years of industry experience, or MS with 8–10+ years.
Extensive hands-on experience with LCUV characterization of biologics, ADCs, or related conjugates.
Experience with protein chemistry and conjugation technologies.

Responsibilities

Lead development, optimization, and transfer of chromatographic analytical methods for ADCs and related bioconjugates.
Design and execute chromatographic studies for characterization of intact proteins/antibodies and conjugated species.
Perform DAR analysis, aggregation/fragmentation and charge variant assessments.
Support regulatory submissions and create analytical development reports and SOPs.