Senior LC-MS Scientist – ADC & Bioconjugate Characterization

Abzena; Bristol Township (Bucks County); On-site; USD 120,000 - 170,000; Full time

Job summary

Abzena in the United States seeks an experienced LC-MS scientist to develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities.

This individual will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.

Qualifications

• Ph.D. in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 5-8 years of industry experience; or MS with 8-10+ years.
• Extensive hands-on experience with LC-MS characterization of biologics, ADCs, or related conjugated therapeutics.
• Hands-on experience with high-resolution mass spectrometry techniques and interpretation of complex datasets.
• Experience with analytical characterization techniques including intact/reduced, subunit mass analysis, and peptide mapping.
• Strong understanding of protein chemistry, conjugation technologies, and biopharmaceutical analytical development.
• Experience with data analysis software such as Waters Connect, MassLynx, or equivalent platforms.
• Excellent technical writing, problem-solving, and communication skills.

Responsibilities

• Lead development, optimization, and transfer of LC-MS analytical methods supporting ADCs and related bioconjugate therapeutics.
• Design and execute MS studies for characterization of intact antibodies, fragments, proteins, peptides, linker-payloads, and conjugated species.
• Perform DAR analysis, peptide mapping, PTM ID, conjugation site analysis, aggregation/fragmentation assessment, and stability studies.
• Support investigations related to process development, deviations, comparability, and product quality.
• Collaborate with PD, bioassay, formulation, and quality teams to define analytical controls and CQAs.
• Develop sample prep workflows for proteins, peptides, oligos, and conjugates for LC-MS.
• Interpret complex datasets and communicate findings to cross-functional teams and sponsors.
• Author technical reports, development summaries, regulatory docs, SOPs, protocols, and qualification reports.
• Support IND/BLA/IMPD analytical sections.
• Maintain instrumentation, troubleshoot, and schedule vendor maintenance/repairs.

Skills

LC-MS characterization

High-resolution MS

Data analysis software

Technical writing

Problem-solving

Communication

Education

Ph.D. in Analytical Chemistry / related

M.S. in related field

Job description

Abzena in the United States seeks an experienced LC-MS scientist to develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities.

This individual will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.