Senior ADC Separations Scientist | Bioconjugate Analytics

Abzena Inc.

Bristol Township (Bucks County)

On-site

USD 120,000 - 180,000

Full time

3 days ago
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Job summary

Abzena, a leading biopharma development partner, seeks an experienced separations scientist to develop advanced chromatographic workflows for conjugate characterization across ADCs and other bioconjugates. You will lead method development, transfer, and industrial-scale analyses to support process development and CMC activities.

The role requires deep knowledge of chromatographic techniques, protein chemistry, and data interpretation, with collaboration across process development, bioassay,

Qualifications

  • PhD or MS with extensive industry experience in analytical characterization of biologics.
  • Hands-on experience with chromatography-based methods for proteins and conjugates.
  • Experience with data analysis software and method development for CGMP projects.

Responsibilities

  • Lead development and transfer of chromatographic methods for ADCs and related bioconjugates.
  • Design studies for characterization of intact antibodies, fragments, and conjugated species.
  • Perform DAR, aggregation, and linker-payload analyses with rigorous data interpretation.
  • Support process development, manufacturing deviations, and comparability assessments.
  • Collaborate with cross-functional teams to establish analytical control strategies.

Skills

LCUV characterization
RPLC/UV
SEC-UV
IEX-UV
Protein chemistry
Data analysis
Technical writing

Education

PhD in Analytical Chemistry
MS in Chemistry

Tools

Waters Empower

Job description

Abzena, a leading biopharma development partner, seeks an experienced separations scientist to develop advanced chromatographic workflows for conjugate characterization across ADCs and other bioconjugates. You will lead method development, transfer, and industrial-scale analyses to support process development and CMC activities.

The role requires deep knowledge of chromatographic techniques, protein chemistry, and data interpretation, with collaboration across process development, bioassay,

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