Senior LC-MS Scientist - ADC & Bioconjugate Characterization

Abzena Inc.; Bristol Township (Bucks County); On-site; USD 120,000 - 160,000; Full time

Job summary

Abzena is seeking an experienced LC-MS scientist to develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities.

This role will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.

Qualifications

• PhD/MS with 5–10 years in LC-MS for biologics or ADCs.
• Hands-on expertise in high-res MS and complex data interpretation.
• Experience with protein/peptide mapping and conjugation analysis.
• Strong technical writing and collaboration skills.

Responsibilities

• Lead LC-MS method development and transfer for ADCs and bioconjugates.
• Design MS studies for intact antibodies, conjugates, and related species.
• Analyze DAR, linker-payload, PTMs, and impurities.
• Support process development, manufacturing deviations, and regulatory sections.
• Collaborate with QA, formulation, and CROs; prepare reports and SOPs.
• Maintain and troubleshoot LC-MS instrumentation.

Skills

LC-MS analysis

Mass spectrometry

Bioconjugates

Data interpretation

Technical writing

Education

PhD in Analytical Chemistry or related

MS with extensive experience

Tools

Waters Connect

MassLynx

Proteomics software

Job description

Abzena is seeking an experienced LC-MS scientist to develop LC-MS methods for conjugate characterization activities supporting process development of antibody-drug conjugates (ADCs), oligonucleotide conjugates, radioconjugates, and other complex bioconjugate modalities.

This role will serve as a technical expert in mass spectrometry-based characterization and method development across process development and CMC activities.