Senior Research Scientist, High-Throughput HT-MS & Robotics

Incyte Corporation; Wilmington (DE); On-site; USD 120,000 - 180,000; Full time

Job summary

Incyte Corporation in Wilmington, Delaware is seeking a Senior Research Scientist to lead the build, implementation and hands-on support of a high-throughput robotics and mass spectrometry laboratory for weekly ADME assays, including metabolic intrinsic clearance, CYP450 inhibition and transporter studies.

The role includes developing LC-MS/MS methods for HT assays, training laboratory staff, and collaborating with cross-functional teams to ensure data quality and timely reporting.

Qualifications

• Bachelor's degree with 10+ years in HT drug metabolism/ADME or PhD with 3+ years in a high-throughput lab.
• Experience with HT-MS platforms (Agilent RapidFire, Sciex Echo) preferred.
• Proficiency with liquid handling robots (Hamilton, Tecan) and programming for ADME assays.

Responsibilities

• Miniaturize end-to-end robotics workflow for weekly ADME assays using HT robotics and MS instruments.
• Develop, analyze, report and archive drug metabolism/ADME data using LC-MS/MS bioanalysis.
• Collaborate with cross-functional stakeholders and lab staff to ensure data quality.
• Perform routine lab tasks: reagent prep, instrument maintenance, and inventory management.
• Analyze and archive data into ELN; prepare summaries and reports as needed.
• Develop LC-MS/MS methods for HT ADME assays and troubleshoot data quality issues.

Skills

HT-MS platforms

Agilent RapidFire

Sciex Echo mass spectrometry

Liquid handling robots

Hamilton

Tecan

LC-MS/MS

Data analysis

ELN documentation

Attention to detail

Education

Bachelor's degree in a relevant scientific discipline

Ph.D. with 3+ years in HT drug metabolism/ADME

Tools

Agilent RapidFire

Sciex Echo

LC-MS/MS

Hamilton

Tecan

Job description

Incyte Corporation in Wilmington, Delaware is seeking a Senior Research Scientist to lead the build, implementation and hands-on support of a high-throughput robotics and mass spectrometry laboratory for weekly ADME assays, including metabolic intrinsic clearance, CYP450 inhibition and transporter studies.

The role includes developing LC-MS/MS methods for HT assays, training laboratory staff, and collaborating with cross-functional teams to ensure data quality and timely reporting.