Senior Proteomics Scientist – High-Throughput Mass Spec

Amgen; Thousand Oaks (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

Amgen’s Thousand Oaks team is seeking a Senior Scientist in mass spectrometry-based proteomics. The role delivers insights to support target identification and drug discovery, while advancing proteomics platform technologies.

You will implement high-throughput workflows and model systems for screening, enabling accelerated discovery and pipeline support. The position requires hands-on expertise with high-throughput MS platforms, data analysis, and cross-functional communication to drive

Qualifications

• PhD/PharmD/MD required or relevant experience in proteomics.
• MS/BS routes with direct related proteomics experience considered.
• Experience with high-throughput mass spectrometry workflows preferred.

Responsibilities

• Design and optimize high-throughput MS-based proteomics workflows.
• Execute automated sample prep and LC-MS/MS analyses across assays.
• Collaborate with chemistry, biology, and disease-area teams.
• Analyze data to reveal mechanism of action, target engagement, and selectivity.

Skills

Mass spectrometry

Proteomics

High-throughput assays

Data analysis

Collaborative work

Education

PhD/PharmD/MD

MS with experience

BS with experience

Tools

Orbitrap Astral

LC-MS/MS

Job description

Amgen’s Thousand Oaks team is seeking a Senior Scientist in mass spectrometry-based proteomics. The role delivers insights to support target identification and drug discovery, while advancing proteomics platform technologies.

You will implement high-throughput workflows and model systems for screening, enabling accelerated discovery and pipeline support. The position requires hands-on expertise with high-throughput MS platforms, data analysis, and cross-functional communication to drive