Proteomics Scientist (Mass Spec) — Flexible Work Options

Amgen

Thousand Oaks (CA)

On-site

USD 115,000 - 156,000

Full time

9 days ago

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Benefits offered by this job

Competitive benefits

Total Rewards Plan

Flexible work options

Job summary

Amgen in Thousand Oaks, California, is seeking a Scientist or Senior Scientist in mass spectrometry–based proteomics to generate proteomic insights that support target identification, drug discovery, and screening technology development.

You will design and implement high-throughput proteomics workflows, perform automated sample preparation and LC–MS/MS analyses, and collaborate with biology and chemistry teams to accelerate the pipeline.

Qualifications

Doctorate degree (PhD, PharmD, or MD) with relevant experience.
OR Master’s degree with 2 years of directly related experience.
OR Bachelor’s degree and 4 years of directly related experience.
Preferred: Doctorate in proteomics, chemoproteomics, biochemistry, chemistry, analytical science, or related.
Hands‑on experience developing, optimizing, and applying mass spectrometry–based proteomics assays and workflows.
Experience operating and troubleshooting advanced LC–MS/MS platforms, such as Orbitrap‑based systems, and analyzing proteomics data.
Experience with high‑throughput sample preparation, miniaturization, and laboratory automation platforms.
Demonstrated ability to develop, refine, or scale assays, analytical methods, or proteomics platforms.
Quantitative and computational experience analyzing complex, high‑dimensional proteomics datasets.
Experience working in a biotechnology, pharmaceutical, or drug‑discovery research environment is preferred.
Ability to work effectively in a highly integrated, collaborative team environment; strong organizational, verbal, and written communication skills; and a demonstrated commitment to generating reliable, reproducible results.

Responsibilities

Design, develop, optimize, and implement high-throughput mass spectrometry–based proteomics workflows and screening platforms to accelerate drug discovery.
Execute automated sample preparation and LC–MS/MS analyses across a broad range of high-throughput proteomics assays.
Collaborate closely with therapeutic area, biology and chemistry teams as a technical and scientific subject‑matter expert, contributing to data‑driven decision‑making.
Analyze and interpret proteomics data to generate insights into mechanism of action, target engagement, selectivity, and other key drug‑discovery questions.
Operate, maintain, troubleshoot, and continuously improve high-throughput mass spectrometry systems and associated analytical workflows.
Present research findings at internal and external meetings, and clearly communicate experimental plans, results, and analyses to cross‑functional teams.
Maintain accurate, organized, and timely documentation of experiments, protocols, methods, and data analyses.