Senior Scientist

Amgen; Thousand Oaks (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

Amgen’s Thousand Oaks team is seeking a Senior Scientist in mass spectrometry-based proteomics. The role delivers insights to support target identification and drug discovery, while advancing proteomics platform technologies.

You will implement high-throughput workflows and model systems for screening, enabling accelerated discovery and pipeline support. The position requires hands-on expertise with high-throughput MS platforms, data analysis, and cross-functional communication to drive

Qualifications

• PhD/PharmD/MD required or relevant experience in proteomics.
• MS/BS routes with direct related proteomics experience considered.
• Experience with high-throughput mass spectrometry workflows preferred.

Responsibilities

• Design and optimize high-throughput MS-based proteomics workflows.
• Execute automated sample prep and LC-MS/MS analyses across assays.
• Collaborate with chemistry, biology, and disease-area teams.
• Analyze data to reveal mechanism of action, target engagement, and selectivity.

Skills

Mass spectrometry

Proteomics

High-throughput assays

Data analysis

Collaborative work

Education

PhD/PharmD/MD

MS with experience

BS with experience

Tools

Orbitrap Astral

LC-MS/MS

Job description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity‑related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award‑winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr Scientist

What You Will Do

Let’s do this. Let’s change the world.

We are seeking a motivated Senior Scientist in mass spectrometry‑based proteomics to join our talented and collaborative team in Thousand Oaks, CA. In this vital role, you will deliver critical insights to support target identification and drug discovery, while advancing innovative proteomics platform technologies.

You will contribute to both pipeline advancement and screening platform innovation by developing and implementing cutting‑edge, high‑throughput proteomics approaches. This includes executing automated sample preparation and mass spectrometry analyses across a range of assays, as well as designing, optimizing, and continuously enhancing next‑generation screening workflows and analytical platforms.

This role requires hands‑on experience operating and troubleshooting high‑throughput mass spectrometry systems. Your work will play a key role in enabling innovative drug screening strategies, accelerating discovery efforts, and strengthening pipeline support.

• Design, develop, and optimize high‑throughput mass spectrometry‑based proteomics workflows and screening platforms to accelerate drug discovery
• Execute automated sample preparation and LC‑MS/MS analysis across a broad range of high‑throughput proteomics assays
• Collaborate closely with chemistry, biology, and disease area teams as a technical and scientific subject matter expert, contributing to data‑driven decision‑making
• Perform data analysis and generate insights into mechanism of action, target engagement, and selectivity using proteomics approaches
• Present research findings at internal and external meetings and effectively communicate plans, results, and analyses to cross‑functional teams
• Maintain accurate and organized documentation of experiments, protocols, and analyses

What We Expect Of You

We are all different, yet we all use our unique contributions to serve patients. The Senior Scientist we seek is a scientifically driven, collaborative, and innovative proteomics expert.

Basic Qualifications:

• Doctorate degree (PhD, PharmD, or MD) with relevant experience OR
• Master’s degree and 4 years of directly related experience OR
• Bachelor’s degree and 6 years of directly related experience

Preferred Qualifications:

• Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, or a related discipline
• Strong track record in developing mass spectrometry‑based proteomics assays, operating advanced platforms (e.g., Orbitrap Astral), and analyzing proteomics data
• Experience with sample preparation miniaturization and automation platforms
• 3+ years of experience in the biotech or pharmaceutical industry
• Demonstrated innovation in assay, method, or platform development
• Strong quantitative and computational expertise in high‑dimensional proteomics data analysis
• Ability to work effectively in a highly integrated, collaborative team environment, with excellent organizational, verbal, and written communication skills, and a proven track record of producing reliable and reproducible results.
• Knowledge of targeted protein degradation or E3 ligase biology is a plus

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.