Discovery Proteomics Scientist – LC-MS/MS Expert

Biopharma Careers; South San Francisco (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

Amgen in South San Francisco seeks an Associate Scientist Discovery Proteomics to advance LC-MS/MS-based research for early discovery projects. You will execute quantitative proteomic workflows to support cell-surface target discovery, proximity labeling, and biomarker studies, collaborating with proteomics, biology, automation, and bioinformatics teams.

The role emphasizes high-quality data generation, rigorous analysis, and cross-functional communication in a fast-paced environment, with

Qualifications

• Master’s degree or higher in analytical chemistry, biochemistry, chemical biology, molecular/cell biology, or related field.
• Hands-on experience with proteomic sample preparation and LC-MS workflows.
• Familiarity with proteomics software (Proteome Discoverer, Spectronaut, DIA-NN).
• Experience with protein enrichment methods and LC-MS performance evaluation.

Responsibilities

• Execute and optimize established proteomics workflows for discovery and targeted approaches (DIA, TMT, label-free, PRM).
• Prepare samples from cell lines and biological matrices using cell-surface protein enrichment and proximity labeling.
• Operate LC-MS systems across vendor platforms, maintain instruments, troubleshoot issues with guidance from senior staff.
• Process and evaluate proteomic data with software and collaborate with bioinformatics to support analysis.
• Communicate plans, progress and results to team and cross-functional partners.
• Maintain detailed records of experiments, instrument performance, and analyses per data-integrity practices.

Skills

LC-MS/MS proteomics

Sample preparation

Data analysis

Communication

Education

Master’s degree

Bachelor’s degree and 2 years of scientific experience

Associate’s degree and 4 years of scientific experience

Tools

Proteome Discoverer

Spectronaut

DIA-NN

Proximity labeling

Tecan

Hamilton

Opentrons

KingFisher

Job description

Amgen in South San Francisco seeks an Associate Scientist Discovery Proteomics to advance LC-MS/MS-based research for early discovery projects. You will execute quantitative proteomic workflows to support cell-surface target discovery, proximity labeling, and biomarker studies, collaborating with proteomics, biology, automation, and bioinformatics teams.

The role emphasizes high-quality data generation, rigorous analysis, and cross-functional communication in a fast-paced environment, with