Senior Process Engineer – Drug Substance & Scale-Up

Eli Lilly and Company; Indianapolis (IN); On-site; USD 129,000 - 209,000; Full time

Job summary

Eli Lilly and Company in Indianapolis, IN, is seeking outstanding engineers to advance synthetic manufacturing processes for small molecules and biochemically related products. You will partner with chemists, analytical chemists, and formulation scientists to accelerate drug substance development while ensuring robust, scalable processes.

The role emphasizes hands-on lab work, process modeling, and technology transfer with opportunities for mentorship and leadership in a collaborative,

Qualifications

• PhD in Chemical Engineering or equivalent with strong leadership and problem-solving skills.
• Experience in chemical/pharmaceutical process development and scale-up.
• Proven ability to work across multidisciplinary teams and document processes.

Responsibilities

• Apply engineering fundamentals to design and optimize chemical processes for small molecules, oligonucleotides, and synthetic peptides.
• Design and execute lab experiments using reaction kinetics, heat/mass transfer, thermodynamics, fluid dynamics, and process modeling.
• Develop proficiency across unit operations including crystallization, filtration, drying, milling, and batch/continuous chemistry.
• Serve on integrated commercialization teams to develop, test, and oversee process execution from lab scale to manufacturing.

Skills

Process design

Process development

Unit operations

Batch & continuous

PAT systems

Data analytics

Modeling & simulation

Leadership

Communication

Education

PhD in Chemical Engineering

MSc in Chemical Engineering +7 years experience

BSc in Chemical Engineering +10 years experience

Tools

Process modeling tools

Job description

Eli Lilly and Company in Indianapolis, IN, is seeking outstanding engineers to advance synthetic manufacturing processes for small molecules and biochemically related products. You will partner with chemists, analytical chemists, and formulation scientists to accelerate drug substance development while ensuring robust, scalable processes.

The role emphasizes hands-on lab work, process modeling, and technology transfer with opportunities for mentorship and leadership in a collaborative,