Senior Principal Statistical Programmer - Remote Expert

WCG Clinical, Inc.; Lansing (MI); Remote; USD 131,000 - 160,000; Full time

Job summary

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer to serve as a technical leader in statistical programming for clinical trials. You will design, validate, and oversee complex outputs, and drive standards, automation, and best practices across studies.

You will mentor staff, collaborate with biostatistics and study teams, and support regulatory submissions with SAS and R expertise in a remote US setting.

Qualifications

• Minimum 8–10 years of statistical programming experience in a clinical trial environment.
• Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
• Proficiency in R programming is a must.
• Demonstrated experience with CDISC standards and regulatory requirements.
• Proven ability to independently lead complex programming efforts across studies.
• Experience mentoring staff and driving technical standards or best practices.
• Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.

Responsibilities

• Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
• Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
• Lead the development, validation, and continuous improvement of DMC macros and programming standards.
• Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
• Drive the establishment and adoption of programming standards, best practices, and process improvements.
• Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
• Independently manage and prioritize programming activities across multiple studies or initiatives.
• Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
• Contribute technical expertise to proposals, project planning, and scope discussions as needed.
• Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
• Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
• Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
• Influence programming approaches, standards, and best practices across multiple studies or programs.
• Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
• Provide expert interpretation of statistical analysis plans (SAPs), protocols, and study documents, translating requirements into programming strategy.
• Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.

Skills

Leadership

Mentoring

Cross-functional collaboration

Regulatory knowledge

Education

Master’s degree

Tools

SAS

R

CDISC

Job description

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer to serve as a technical leader in statistical programming for clinical trials. You will design, validate, and oversee complex outputs, and drive standards, automation, and best practices across studies.

You will mentor staff, collaborate with biostatistics and study teams, and support regulatory submissions with SAS and R expertise in a remote US setting.