Remote Senior Principal Statistical Programmer Leader

WCG Clinical, Inc.; Santa Fe (NM); Remote; USD 131,000 - 160,000; Full time

Job summary

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer to drive complex programming in support of clinical trials and DMC deliverables. You will design, develop, validate, and standardize outputs while providing expert guidance across projects.

The role is remote in the US, focusing on collaborating with biostatistics, data management, and IT to ensure high-quality, compliant submissions and CDISC alignment.

Qualifications

• Minimum 8–10 years of statistical programming experience in a clinical trial environment.
• Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
• Proficiency in R programming is a must.
• Demonstrated experience with CDISC standards and regulatory requirements.
• Proven ability to independently lead complex programming efforts across studies.
• Experience mentoring staff and driving technical standards or best practices.
• Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities.

Responsibilities

• Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
• Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
• Lead the development, validation, and continuous improvement of DMC macros and programming standards.
• Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
• Drive the establishment and adoption of programming standards, best practices, and process improvements.
• Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
• Independently manage and prioritize programming activities across multiple studies or initiatives.
• Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
• Provide expert interpretation of SAPs, protocols, and study documents, translating requirements into programming strategy.
• Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.

Skills

Mentoring staff

Technical leadership

Cross-functional collaboration

Independent project coordination

Strategic thinking on standards

Education

Master’s degree in a relevant field

Tools

SAS programming

R programming

CDISC standards

Job description

WCG Clinical, Inc. is seeking a Senior Principal Statistical Programmer to drive complex programming in support of clinical trials and DMC deliverables. You will design, develop, validate, and standardize outputs while providing expert guidance across projects.

The role is remote in the US, focusing on collaborating with biostatistics, data management, and IT to ensure high-quality, compliant submissions and CDISC alignment.