Senior Principal Scientist - Immuno-Oncology Biology Lead

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); On-site; USD 132,000 - 246,000; Full time

Job summary

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA, seeks a highly collaborative scientist to lead biology and drug-discovery efforts for novel immune cell engagers and multispecific immune modulators, combining cancer-immunology expertise with cross-functional leadership to advance programs toward clinical development.

The role involves leading strategy, supervising scientists, and coordinating across antibody engineering, translational science, pharmacology, safety, and data

Qualifications

• PhD in cancer biology or immunology with 5+ years of research/industry experience, or MS with 10+ years.
• Strong expertise in cancer biology/immunology (T cell and/or myeloid biology).
• Expertise in tumor immunology, especially T cell–mediated anti-tumor activity and tumor-associated myeloid biology.
• Proficient in immune-cell functional assays and multiparameter flow cytometry.
• Experience in antibody, multispecific biologic and/or immune-engager discovery within cross-functional teams.
• Ability to formulate hypotheses, design rigorous experiments, interpret complex data and translate findings into project decisions, evidenced by publications.
• Excellent communication, presentation, analytical and collaboration skills.

Responsibilities

• Identify and validate tumor-targeting strategies for immune cell engagers and multispecific modulators.
• Lead biology strategy and execution for multidisciplinary drug-discovery programs, defining goals and decision criteria.
• Serve as project team leader, integrating antibody engineering and translational biology.
• Design and interpret mechanistic studies of immune activation, anti-tumor activity, and safety-relevant biology.
• Present evidence-based recommendations and development plans at governance reviews.
• Supervise and develop scientists while building collaborations.
• Contribute to immune-engager strategy and next-generation modality innovation.

Skills

Cancer biology

Immunology

T cell biology

Myeloid biology

Immune cell assays

Flow cytometry

Antibody discovery

Data interpretation

Publications

Cross-functional collaboration

Education

PhD in cancer biology or immunology

MS with 10+ years industry experience

Tools

Flow cytometry software

Job description

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA, seeks a highly collaborative scientist to lead biology and drug-discovery efforts for novel immune cell engagers and multispecific immune modulators, combining cancer-immunology expertise with cross-functional leadership to advance programs toward clinical development.

The role involves leading strategy, supervising scientists, and coordinating across antibody engineering, translational science, pharmacology, safety, and data