Senior Immunology Scientist, xRNA Biotherapeutics

Novartis Group Companies; Cambridge (MA); On-site; USD 99,000 - 183,000; Full time

Job summary

Novartis Group of Companies in Cambridge, MA seeks a Senior Scientist with strong immunology and immune profiling experience to lead mechanistic studies on biotherapeutics such as AOC and xRNA modalities. The role focuses on immune cell activation, cytokine responses, and integrating data across discovery and early development programs.

The successful candidate will design immune profiling strategies, generate mechanistic data packages, and collaborate across immunology, oligonucleotide biology,

Qualifications

• Ph.D. or MSc in Life Science with experience in immunology or cell biology
• Deep expertise in human immunology and immune assay development using primary cells or disease-relevant models
• Experience assessing immunogenicity and immune liabilities for biologics or novel modalities
• Proficiency with readouts such as flow cytometry, immunoassays, qPCR, transcriptomics or imaging
• Strong data analysis, experimental design, and communication skills

Responsibilities

• Design and execute immunology-focused profiling strategies to evaluate immune cell functions and disease-relevant outcomes
• Execute and analyze complex assays using primary cells and multicolor FACS
• Generate hypotheses, design experiments, and interpret data to guide study decisions
• Create mechanistic immunology data packages to inform candidate optimization and safety assessment
• Collaborate with immunology, disease biology, oligonucleotide biology, and other teams to align assay strategies
• Regularly communicate results and present to project teams
• Be proactive in developing new assays or analysis tools as needed

Skills

Immunology

Flow cytometry

Immunoassays

qPCR

Transcriptomics

Education

Ph.D. in Life Science

MSc in Life Science

Tools

Multicolor FACS

Transcriptomics

Job description

Novartis Group of Companies in Cambridge, MA seeks a Senior Scientist with strong immunology and immune profiling experience to lead mechanistic studies on biotherapeutics such as AOC and xRNA modalities. The role focuses on immune cell activation, cytokine responses, and integrating data across discovery and early development programs.

The successful candidate will design immune profiling strategies, generate mechanistic data packages, and collaborate across immunology, oligonucleotide biology,