Immuno-Oncology Scientist (Senior I/II) - Onsite Cambridge

U175 (FCRS = US175) Novartis Institutes for BioMedical Research, Inc.; Cambridge (MA); On-site; USD 99,000 - 183,000; Full time

Benefits offered by this job

Health, life & disability

401(k) match

Generous vacation/Leave

Job summary

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA is seeking a Senior Scientist to join the Oncology Immune Therapies group.

You will contribute to drug discovery through in vitro and in vivo studies, develop cell-based and molecular assays, and collaborate across functional teams to advance cancer immunology programs. Qualified candidates have a Bachelor’s degree in immunology or related field, 5+ years of industry experience, and expertise in tumor immunology and flow

Qualifications

• Bachelor’s degree in immunology, immuno-oncology, oncology, molecular or cell biology, or a related field is required.
• A master’s degree is preferred.
• 5+ years of relevant laboratory experience in industry.
• Knowledge of immunology and expertise in cancer biology and/or immunology are required.
• Expertise in tumor immunology, especially T cell mediated anti-tumor activity is highly desired.
• Proficiency in cell culture including cell lines and primary cells, and multi-color flow cytometry is required.
• Extensive hands-on experience with immune cell-based assays, including primary immune cell isolation, manipulation, phenotyping, and in vitro functional assays, as well as mammalian cell line culture is highly desired.
• Experience with molecular cloning, qPCR, reporter assays, ELISA, viral production and transduction, mRNA-LNP–mediated gene expression in primary cells, gene silencing (RNAi or CRISPR), or other target validation methods is a plus.
• Demonstrated ability to quickly learn and perform in new areas, implement new techniques and instrumentation.
• Strong scientific motivation and rigor, with experience independently designing, developing, executing, and troubleshooting cell-based assays for drug discovery, are preferred.
• Excellent presentation, written and verbal communication, and interpersonal skills, with the ability to thrive in a fast-paced, collaborative environment.
• A record of accomplishments with peer-reviewed publications a plus.

Responsibilities

• Support drug screening, target identification and validation using lentiviruses, mRNA-LNP, cells, and tissues.
• Develop and perform cell-based assays, flow cytometry, and biochemistry-based assays for drug discovery.
• Conduct molecular biology techniques (e.g., gel electrophoresis, cloning, qPCR, western blot).
• Perform analyses of preclinical tissue samples provided by the in vivo team.
• Record data, maintain documentation, and ensure GMP-like practices.
• Collaborate in a matrixed environment and present results in meetings.
• Assist in writing research documents and publications.

Skills

Immunology

Cancer biology

T cell immunology

Flow cytometry

Cell culture

Molecular cloning

qPCR

ELISA

mRNA-LNP

Viral production

Education

Bachelor’s degree in immunology/related field

Master’s degree preferred

Tools

Lentiviral handling

Western blot

PCR/qPCR

Viral transduction

mRNA-LNP techniques

Cell-based assays

Job description

Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA is seeking a Senior Scientist to join the Oncology Immune Therapies group.

You will contribute to drug discovery through in vitro and in vivo studies, develop cell-based and molecular assays, and collaborate across functional teams to advance cancer immunology programs. Qualified candidates have a Bachelor’s degree in immunology or related field, 5+ years of industry experience, and expertise in tumor immunology and flow