Senior Preclinical DMPK Modeling Leader

ViiV Healthcare; Upper Providence (Delaware County); On-site; USD 141,000 - 235,000; Full time

Job summary

ViiV Healthcare is seeking a Scientific Leader for Pre-clinical DMPK Drug Discovery Modeling. The role focuses on mechanistic and translational modeling (PBPK, IVIVE, PK/PD) to guide candidate selection and development decisions.

Based in the US with relocation to Branford, CT or Upper Providence, PA or Waltham, MA or Durham, NC, you will lead modeling efforts across modalities and contribute to scientific publications and regulatory submissions.

Qualifications

• Master's degree with 7+ years post-graduate experience or PhD with 4+ years in drug discovery programs.
• Strong understanding of ADME principles and integration of DMPK workflows into empirical and mechanistic modeling.
• Ability to apply modeling to lead optimization, dose projection, and development strategy.
• Broad computational programming expertise to develop modeling workflows.
• Experience integrating diverse datasets into predictive modeling platforms.
• Ability to communicate results to cross-functional teams and leadership.

Responsibilities

• Develop and apply mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide discovery teams.
• Translate ADME, PK, PD data into actionable insights for project teams and leadership.
• Apply modeling across modalities, formulations, and routes, including long-acting therapies.
• Build scalable computational tools, workflows, and prototypes for faster decisions.
• Establish governance for modeling methodologies and workflows.
• Contribute to scientific publications and regulatory submissions; represent ViiV externally.

Skills

ADME

Analytical Chemistry

Drug Design

Drug Discovery

Drug Metabolism

Pharmacokinetics

Pharmacology

PBPK Modeling

Regulatory Submissions

Cross-functional communication

Target Research

Education

Master's degree with 7+ years

PhD with 4+ years

Tools

R

Python

Simcyp

GastroPlus

Phoenix WinNonLin

Job description

ViiV Healthcare is seeking a Scientific Leader for Pre-clinical DMPK Drug Discovery Modeling. The role focuses on mechanistic and translational modeling (PBPK, IVIVE, PK/PD) to guide candidate selection and development decisions.

Based in the US with relocation to Branford, CT or Upper Providence, PA or Waltham, MA or Durham, NC, you will lead modeling efforts across modalities and contribute to scientific publications and regulatory submissions.