Director, PK/PD & QSP Modeling - Lead Therapy Programs

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 172,000 - 237,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Flagship Pioneering is seeking a highly motivated leader to provide leadership and hands-on support for modeling efforts (PK/PD/QSP) across its diverse drug discovery portfolio. You will guide internal and external due diligence and help accelerate timelines from Lead ID to DC while applying innovative modeling to inform early feasibility concepts.

As programs advance, you will integrate modeling workstreams into cross-functional development strategy and, in collaboration with clinical teams,

Qualifications

• PhD. in pharmacology, engineering sciences, (bio-)physics or applied mathematics with 5+ years of experience in QSP and/or PK/PD modeling; 8+ years, including direct experience managing scientists and/or CRO relationships, is expected for the Director level
• Advanced experience in QSP modeling workflows, deep understanding of mechanistic, physiologically‑based modeling principles and biological subject matter expertise in at least one disease area; familiarity with population PK/PD and experience with AI‑supported and/or agentic modeling workflows desirable
• Programming skills (e.g., R, Python, Matlab), hands‑on modeling experience using Simbiology, NONMEM, Monolix, Pumas, or similar software packages
• Experience supporting drug discovery programs including due diligence and early feasibility assessments
• Excellent oral and written communication skills with the ability to work in a multidisciplinary team with colleagues and collaborators representing diverse backgrounds
• Track record of representing scientific work externally (e.g., publications, conference presentations, scientific advisory interactions) is a plus

Responsibilities

• Work with cross-functional development teams and platform companies to identify modeling needs, model complexity and required data
• Develop QSP and PK/PD models for various modalities and therapeutic areas
• Provide guidance to early-stage Flagship companies to help accelerate timelines from Lead ID to DC
• Utilize AI-supported modeling workflows to provide end-to-end modeling support including model scoping, model development, model calibration and analysis
• Ensure that supporting infrastructure (software, methods, external consulting support, etc.) is efficient and meets all required standards.
• Manage (Director) a small team of modeling scientists and CROs, including scientific oversight, budget, and timeline accountability for externalized model development

Job description

Flagship Pioneering is seeking a highly motivated leader to provide leadership and hands-on support for modeling efforts (PK/PD/QSP) across its diverse drug discovery portfolio. You will guide internal and external due diligence and help accelerate timelines from Lead ID to DC while applying innovative modeling to inform early feasibility concepts.

As programs advance, you will integrate modeling workstreams into cross-functional development strategy and, in collaboration with clinical teams,