Associate Principal Scientist, DMPK & PK/PD

Caraway Therapeutics; United States; On-site; USD 142,000 - 224,000; Full time

Job summary

Merck & Co., Inc. in West Point, PA seeks an Associate Principal Scientist to lead DMPK analyses, integrating PK/PD and DDI risk assessment across modalities.

You will collaborate with cross-functional teams to support discovery and clinical development, guiding in silico, in vitro, and in vivo studies, and contributing to regulatory filings. The role requires strong leadership, collaboration, and communication, with experience spanning preclinical and translational modeling and a track record

Qualifications

• 8+ years relevant industry experience in discovery and development of therapeutics of various modalities.
• Integrating preclinical DMPK and pharmacology to enable translational modeling and simulation.
• Experience in dose selection, PK/PD and safety assessment studies.
• Experience communicating analyses to interdisciplinary teams and management.
• Experience authoring IB, IND, WMA filings and regulatory responses.
• Demonstrated collaboration on multi-disciplinary discovery and development teams.
• Strong leadership, interpersonal, communication, problem solving and collaboration skills.

Responsibilities

• Work within cross-functional teams to contribute to discovery and clinical development of therapeutics.
• Guide design and interpretation of in silico, in vitro, and in vivo analyses for DMPK.
• Assess DDI risk using static mechanistic and PBPK models and advise on DDI strategy.
• Author source reports and regulatory filing documents.
• Evaluate program risks and implement strategies to ensure efficient progression and decisions.

Skills

DMPK

Pharmacokinetics

PBPK modeling

In vitro/in vivo

Dose planning

Regulatory filings

Cross-functional

Leadership

LC-MS

Bioanalytical

Education

Pharmaceutical Sciences (B.S./M.S./Ph.D.)

Tools

Phoenix

SimCYP

Job description

Merck & Co., Inc. in West Point, PA seeks an Associate Principal Scientist to lead DMPK analyses, integrating PK/PD and DDI risk assessment across modalities.

You will collaborate with cross-functional teams to support discovery and clinical development, guiding in silico, in vitro, and in vivo studies, and contributing to regulatory filings. The role requires strong leadership, collaboration, and communication, with experience spanning preclinical and translational modeling and a track record