Senior DMPK Modeling Leader - Preclinical Drug Discovery (Hybrid)

GSK; Connecticut; Hybrid; USD 160,000 - 216,000; Full time

Benefits offered by this job

Relocation package

Job summary

ViiV Healthcare is seeking a Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling, to drive model-informed drug discovery across the Drug Discovery organization. You will develop PBPK, IVIVE, and PK/PD models to support rapid decisions in HIV programs and guide dose projections for diverse modalities.

The role partners with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early clinical candidates, with opportunities to publish and influence strategy.

Qualifications

• Master’s degree with 7+ years of post-graduate experience, or a PhD with 4+ years of post-graduate experience, supporting drug discovery programs from lead optimization to Phase I clinical studies.
• Strong understanding of ADME principles and integration of standard DMPK workflows into empirical and mechanistic modeling approaches such as PBPK and PK/PD.
• Demonstrated ability to apply modeling and simulation approaches to influence lead optimization, candidate selection, dose projection, and development strategy.

Responsibilities

• Develop and apply fit-for-purpose mechanistic and translational models (PBPK, IVIVE, PK/PD) to guide drug discovery teams.
• Translate complex ADME, PK, PD, and translational data into actionable insights for project teams.
• Apply modeling expertise across diverse modalities and routes of administration, including long-acting therapies.
• Build scalable computational tools, workflows, and prototypes to accelerate discovery decisions.
• Establish best practices, standards, and governance for modeling methodologies and workflows.
• Contribute to scientific publications, regulatory submissions, and external thought leadership.

Skills

ADME

Analytical Chemistry

Drug Design

Drug Discovery Process

Pharmacokinetics

PBPK Modeling

Drug Metabolism

Drug Research

Regulatory Submissions

Education

Master’s degree

PhD

Tools

Simcyp

GastroPlus

Phoenix WinNonLin

Job description

ViiV Healthcare is seeking a Scientific Leader, Pre-clinical DMPK Drug Discovery Modeling, to drive model-informed drug discovery across the Drug Discovery organization. You will develop PBPK, IVIVE, and PK/PD models to support rapid decisions in HIV programs and guide dose projections for diverse modalities.

The role partners with DMPK, Medicinal Chemistry, Biology, and Clinical Pharmacology to enable early clinical candidates, with opportunities to publish and influence strategy.