Analytical Development Scientist - Biologics (ADC/Covalent)

Enlaza Therapeutics; San Diego (CA); On-site; USD 95,000 - 135,000; Full time

Benefits offered by this job

Stock options

Equity

Health insurance

401(k)

Employee assistance program

Flexible spending account

Flexible vacation

Paid holidays

Relocation assistance (if eligible)

Vision insurance

Year-end shutdown

Job summary

Enlaza Therapeutics in San Diego is seeking an Analytical Development Scientist to advance LC-MS-based characterization of antibodies, ADCs, and complex biologics. You will perform intact mass, peptide mapping, PTM assessments, and disulfide mapping while supporting stability studies and method development.

Join a collaborative team focused on covalent biologics; this role offers growth into a Scientist level with mentorship and cross-functional project exposure.

Qualifications

• Ph.D. in analytical chemistry, biochemistry, or closely related field; 0–2 years of industry experience in analytical development for protein biopharmaceuticals.
• Advanced MS techniques for protein characterization, including disulfide mapping, PTM mapping, and molecular heterogeneity assessment.
• Experience with biophysical characterization to evaluate stability, aggregation, and conformational integrity.

Responsibilities

• Design and perform LC-MS-based characterization, including intact mass, subunit analysis, peptide mapping, PTM assessment, disulfide mapping, and heterogeneity analysis.
• Execute routine protein/antibody separations (SEC, HIC, IEX, icIEF, CE-SDS).
• Troubleshoot and optimize methods for antibodies, ADCs, and other engineered proteins.
• Analyze data, troubleshoot unexpected results, and communicate findings.
• Maintain electronic lab notebooks and assist in protocols/reports.
• Evaluate emerging analytical technologies and implement fit-for-purpose methods.
• Lead analytical initiatives and mentor junior team members for Scientist level.

Skills

Mass spectrometry for protein

Communication skills

Protein data interpretation

Education

Ph.D. in analytical chemistry/biochemistry or closely related field

Tools

Protein Metrics Software Suite

Job description

Enlaza Therapeutics in San Diego is seeking an Analytical Development Scientist to advance LC-MS-based characterization of antibodies, ADCs, and complex biologics. You will perform intact mass, peptide mapping, PTM assessments, and disulfide mapping while supporting stability studies and method development.

Join a collaborative team focused on covalent biologics; this role offers growth into a Scientist level with mentorship and cross-functional project exposure.