Senior LC-MS Bioanalytical Scientist (GLP/ADC)

Actalent; Washington; On-site; USD 120,000 - 190,000; Full time

Job summary

Actalent is seeking an LC-MS Principal Research Scientist to lead pre-clinical GLP bioanalytical method development, validation, and sample analysis using triple quadrupole LC‑MS/MS. The role covers small and large molecules, ADCs, and complex workflows, with direct technical leadership and client-facing collaboration.

You will ensure GLP compliance, generate high‑quality reports, and supervise lab activities in a fast‑paced, teamwork‑driven environment.

Qualifications

• Bachelor’s degree in Immunology, Biology, Chemistry or related field.
• Minimum 5 years GLP laboratory experience in bioanalytical science.
• Experience with LC-MS/MS in a CRO or bio/pharma setting.
• Strong documentation skills ensuring data integrity (ALCOA+).
• Experience with triple quadrupole LC-MS systems for method development.
• Ability to work under GLP, FDA ICH guidelines and SOPs.

Responsibilities

• Lead method development and validation for small and large molecule analysis using LC‑MS/MS.
• Act as SME for pre‑clinical GLP studies and ADC/large molecule workflows.
• Collaborate with clients and internal teams to deliver quality reports.
• Ensure compliance with GLP, SOPs, and QA requirements across studies.
• Prepare study documentation and maintain chain of custody for samples.
• Provide scientific leadership and supervision of laboratory activities.
• Assist with instrument calibration, maintenance, and data collection.
• Communicate updates to clients through calls and reports.

Skills

LC-MS/MS analysis

GLP compliance

Triple quadrupole LC-MS/MS

ADCs & large molecules

Documentation ALCOA+

Client communication

Education

Bachelor’s in Immunology, Biology, or Chemistry

Tools

Shimadzu LC-MS

SCIEX LC-MS/MS

Watson LIMS / data management

Job description

Actalent is seeking an LC-MS Principal Research Scientist to lead pre-clinical GLP bioanalytical method development, validation, and sample analysis using triple quadrupole LC‑MS/MS. The role covers small and large molecules, ADCs, and complex workflows, with direct technical leadership and client-facing collaboration.

You will ensure GLP compliance, generate high‑quality reports, and supervise lab activities in a fast‑paced, teamwork‑driven environment.