LC-MS Bioanalytical Scientist — Accelerate Drug Discovery

Amgen; Thousand Oaks (CA); On-site; USD 109,000 - 147,000; Full time

Job summary

Amgen seeks a Scientist - LC-MS Bioanalytical to advance quantitative LC-MS/MS methods for diverse modalities, including small molecules, oligonucleotides, and proteins.

The role supports discovery through GLP/regulatory activities, collaborates with multidisciplinary teams, and drives automation modernization to enhance throughput and sensitivity. Strong problem-solving and project leadership are essential.

Qualifications

• Doctorate degree required.
• Master’s degree with 2+ years industrial/technical experience.
• Or Bachelor’s degree with 4+ years industrial/technical experience.
• Preferred CRO/pharma/biotech experience.
• Expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms and HRMS.
• Automation and/or micro-sampling in bioanalysis workflows.

Responsibilities

• Plan, execute, and document quantitative LC-MS/MS bioanalytical experiments.
• Develop and implement fit-for-purpose bioanalytical methods with rapid turnaround.
• Perform bioanalysis in matrices including plasma, urine, CSF, and tissues.
• Prepare samples using precipitation, SPE, affinity capture, and related methods.
• Analyze and present bioanalytical data with emphasis on data integrity.
• Maintain documentation in ELNs and compliant systems.
• Ensure data meets regulatory requirements for global submissions.
• Author and review study reports, methods, SOPs, memos, and regulatory documents.
• Communicate results to discovery and development teams; contribute to publications.
• Support report quality control and cross-functional communication.
• Follow safety and site procedures; perform routine lab housekeeping.

Skills

Scientific problem-solving

Project management

Team collaboration

Mentoring

Data interpretation

Education

Doctorate degree

Master’s degree + 2 years experience

Bachelor’s degree + 4 years experience

Tools

KingFisher APEX/FLEX

Automated SPE systems

Robotic liquid handlers

Job description

Amgen seeks a Scientist - LC-MS Bioanalytical to advance quantitative LC-MS/MS methods for diverse modalities, including small molecules, oligonucleotides, and proteins.

The role supports discovery through GLP/regulatory activities, collaborates with multidisciplinary teams, and drives automation modernization to enhance throughput and sensitivity. Strong problem-solving and project leadership are essential.