Senior HPC Infrastructure Engineer (Remote)

Guardant Health; United States; Hybrid; USD 147,000 - 214,000; Full time

Job summary

Guardant Health is seeking a Staff-level HPC engineer to own and scale our HPC infrastructure, with deep depth in Red Hat Linux, networking, storage, Kubernetes or Slurm. You will collaborate across IT, SQA, DevOps/SRE and MSP to deliver reliable, scalable HPC services for oncology data processing.

The role emphasizes 24/7 on-call coverage, on-site hybrid work in the US, and close partnership with vendors and offshore consultants to drive resilient infrastructure.

Qualifications

• Bachelor’s degree in Computer Science or related field with 8–12 years of relevant experience; Master’s with 6–8 years; or PhD with 3–5 years.
• Strong experience in systems/infrastructure engineering, Linux/Unix administration and TCP/IP networking.
• Hands-on automation with Ansible or equivalent tooling.
• Experience with high-performance networking tech, including InfiniBand/RDMA and troubleshooting.
• Experience supporting large-scale storage and HPC/compute environments.
• Experience in on-prem and cloud-based infrastructure (AWS/GCP/Azure).
• Experience with software release, operations and infrastructure automation processes, plus strong documentation.

Responsibilities

• Manage multiple HPC clusters and cluster file systems.
• Integrate cloud bursting as part of HPC abstraction work.
• Develop next generation HPC solutions and troubleshoot production stack to code level.
• Maintain and monitor infrastructure and provide 24/7 on-call rotation.
• Collaborate across networking, storage, SQA, DevOps/SRE and MSP.
• Mentor junior engineers on HPC best practices.
• Work with offsite consultants and vendors to upgrade systems.

Skills

Linux/Unix

TCP/IP networking

Automation (Ansible)

High-performance networking

SRE/DevOps collaboration

Shell scripting

Cross-functional teamwork

Education

Bachelor’s degree in CS or related field

Master’s or PhD in related field (optional)

Tools

Ansible

GPFS

Slurm

Docker

Kubernetes

Warewulf

InfiniBand/ RDMA

Red Hat Linux

Job description

Guardant Health is seeking a Staff-level HPC engineer to own and scale our HPC infrastructure, with deep depth in Red Hat Linux, networking, storage, Kubernetes or Slurm. You will collaborate across IT, SQA, DevOps/SRE and MSP to deliver reliable, scalable HPC services for oncology data processing.

The role emphasizes 24/7 on-call coverage, on-site hybrid work in the US, and close partnership with vendors and offshore consultants to drive resilient infrastructure.