Senior CNS Histology & Imaging Associate

Arbor-Biotechnologies-Inc; Cambridge (MA); On-site; USD 85,000 - 95,000; Full time

Benefits offered by this job

Bonus & equity

Paid parking or transit

12 weeks parental leave

401(k) match

Discretionary time off

HSA health plan premium coverage

Job summary

Arbor Biotechnologies in Cambridge, MA, is seeking a Histology Scientist to generate and quantify tissue-level data from rodent and non-human primate CNS samples to support CNS gene editing programs.

You will develop, optimize, and run IHC, IF, and ISH/RNAscope assays, analyze data in HALO/QuPath/ImageJ, and present findings to cross-functional teams. This on-site role reports to the Senior Scientist, In Vivo Pharmacology.

Qualifications

• Bachelor’s degree with 3+ years in industry or Master’s with 1+ year.
• Developed, optimized, and run IHC/IF/ISH/RNAscope assays; automated staining preferred.
• Worked with CNS tissue from rodent models; non-human primate tissue experience preferred.
• Quantitative image analysis of CNS histology/readouts in HALO/QuPath/ImageJ.
• Kept detailed experimental records and presented data to a project team.
• Experience in gene therapy, gene editing, AAV, or CNS programs preferred.

Responsibilities

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
• Process, stain, and image CNS tissue from rodent and non-human primate studies.
• Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
• Generate histology data to assess biodistribution, target engagement, PD activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional study discussions.
• Troubleshoot assays, improve workflows, and maintain accurate records.

Skills

IHC/IF/ISH assays

CNS tissue work

Image analysis (HALO/QuPath/ImageJ)

Data presentation to project teams

Gene therapy / gene editing exposure

Education

Bachelor’s in biology/neuroscience/pharmacology or related (3+ years) / Master’s (1+ year)

Tools

HALO

QuPath

ImageJ/Fiji

GraphPad Prism

Job description

Arbor Biotechnologies in Cambridge, MA, is seeking a Histology Scientist to generate and quantify tissue-level data from rodent and non-human primate CNS samples to support CNS gene editing programs.

You will develop, optimize, and run IHC, IF, and ISH/RNAscope assays, analyze data in HALO/QuPath/ImageJ, and present findings to cross-functional teams. This on-site role reports to the Senior Scientist, In Vivo Pharmacology.