CNS Histology & Imaging Associate (IHC/ISH) – Preclinical

Arbor Biotechnologies; Cambridge (MA); Presencial; USD 85.000 - 95.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Bonus program

Equity grant

Parental leave 12 weeks

Parking or transit benefits

Descripción de la vacante

Arbor Biotechnologies, a clinical stage gene editing company in Cambridge, MA, seeks a scientist to run histology assays on CNS tissue from rodent and non-human primates. You will quantify readouts and generate data to guide program decisions, presenting results to cross-functional teams.

Requires 3+ years in industry with experience in IHC/IF/ISH and CNS tissue analysis; experience with HALO/QuPath/ImageJ is preferred. On-site role with opportunities for growth and collaboration.

Formación

• Bachelor’s degree in biology, neuroscience, pharmacology, or related field; 3+ years in industry, or Master’s with 1+ year.
• Experience developing, optimizing, and running IHC, IF, or ISH/RNAscope assays; automated staining platform experience preferred.
• Experience with CNS tissue from rodent models; non-human primate tissue experience preferred.
• Quantitative image analysis of CNS histology or ISH readouts in HALO, QuPath, ImageJ/Fiji, or similar tools.
• Detailed experimental records and ability to present data to a project team.
• Experience in gene therapy, gene editing, AAV, or CNS programs preferred.

Responsabilidades

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
• Process, stain, and image CNS tissue from rodent and non-human primate studies.
• Quantify assay readouts in HALO, QuPath, or ImageJ/Fiji.
• Generate histology data to assess biodistribution, target engagement, PD activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional study discussions.
• Troubleshoot assays, improve workflows, and maintain accurate experiment records.

Conocimientos

IHC

IF

ISH/RNAscope

Image analysis

CNS tissue

Educación

Bachelor’s degree in biology/neuroscience/pharmacology or related

Master’s degree

Herramientas

HALO

QuPath

ImageJ/Fiji

GraphPad Prism

Descripción del empleo

Arbor Biotechnologies, a clinical stage gene editing company in Cambridge, MA, seeks a scientist to run histology assays on CNS tissue from rodent and non-human primates. You will quantify readouts and generate data to guide program decisions, presenting results to cross-functional teams.

Requires 3+ years in industry with experience in IHC/IF/ISH and CNS tissue analysis; experience with HALO/QuPath/ImageJ is preferred. On-site role with opportunities for growth and collaboration.