Senior Research Associate, Histology

Arbor-Biotechnologies-Inc; Cambridge (MA); On-site; USD 85,000 - 95,000; Full time

Benefits offered by this job

Bonus & equity

Paid parking or transit

12 weeks parental leave

401(k) match

Discretionary time off

HSA health plan premium coverage

Job summary

Arbor Biotechnologies in Cambridge, MA, is seeking a Histology Scientist to generate and quantify tissue-level data from rodent and non-human primate CNS samples to support CNS gene editing programs.

You will develop, optimize, and run IHC, IF, and ISH/RNAscope assays, analyze data in HALO/QuPath/ImageJ, and present findings to cross-functional teams. This on-site role reports to the Senior Scientist, In Vivo Pharmacology.

Qualifications

• Bachelor’s degree with 3+ years in industry or Master’s with 1+ year.
• Developed, optimized, and run IHC/IF/ISH/RNAscope assays; automated staining preferred.
• Worked with CNS tissue from rodent models; non-human primate tissue experience preferred.
• Quantitative image analysis of CNS histology/readouts in HALO/QuPath/ImageJ.
• Kept detailed experimental records and presented data to a project team.
• Experience in gene therapy, gene editing, AAV, or CNS programs preferred.

Responsibilities

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
• Process, stain, and image CNS tissue from rodent and non-human primate studies.
• Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
• Generate histology data to assess biodistribution, target engagement, PD activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional study discussions.
• Troubleshoot assays, improve workflows, and maintain accurate records.

Skills

IHC/IF/ISH assays

CNS tissue work

Image analysis (HALO/QuPath/ImageJ)

Data presentation to project teams

Gene therapy / gene editing exposure

Education

Bachelor’s in biology/neuroscience/pharmacology or related (3+ years) / Master’s (1+ year)

Tools

HALO

QuPath

ImageJ/Fiji

GraphPad Prism

Job description

Arbor Biotechnologies, a clinical stage, next-generation gene editing company based in Cambridge, MA, is advancing a portfolio of first-in-class genomic medicines addressing serious diseases for which there are no existing functional cures, with a CNS pipeline initially prioritizing multiple ALS targets and a co-developed, clinical program, ABO-101, for the treatment of primary hyperoxaluria type 1. The company’s unique breadth of gene editing technologies goes beyond the limitations of early editing approaches to unlock access to new gene targets and expand the therapeutic reach of genomic medicines. For more information, please visit: arbor.bio .

Who thrives here.

You're driven by purpose and curious by nature. You take ownership, speak up, and stay steady when things get hard. You'd rather the team win than get the credit. If that sounds like you, keep reading.

Why this role matters.

Before any of our CNS gene editing programs can move toward the clinic, we need to see in tissue where an editor went, whether it reached its target, and what it did there. This role produces that evidence. You’ll run and quantify the histology assays on rodent and non-human primate tissue that our program teams use to decide what moves forward.

This role reports to the Senior Scientist, In Vivo Pharmacology. It is on-site in Cambridge, typically 4-5 days per week.

What you'll own.

• Develop, optimize, and run IHC, IF, and ISH/RNAscope assays on preclinical CNS tissue.
• Process, stain, and image CNS tissue from rodent and non-human primate studies.
• Quantify assay readouts in image analysis software such as HALO, QuPath, or ImageJ/Fiji.
• Generate the histology data used to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize them clearly for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional study discussions.
• Troubleshoot assays, improve workflows, and keep experimental records and sample tracking accurate.

What you've done.

• Bachelor’s degree in biology, neuroscience, pharmacology, or a related field with 3+ years of industry experience, or a master’s degree with 1+ year.
• Has developed, optimized, and run IHC, IF, or ISH/RNAscope assays; automated staining platform experience preferred.
• Has worked with CNS tissue from rodent models; non-human primate tissue experience preferred.
• Has performed quantitative image analysis of CNS histology or ISH readouts in HALO, QuPath, ImageJ/Fiji, or a comparable tool.
• Has kept detailed experimental records and presented data to a project team.
• Has worked on gene therapy, gene editing, AAV, or CNS programs (preferred).

What you'll get.

The anticipated base salary range for this role is $85,000–$95,000. Actual pay depends on relevant experience, skills, education, internal equity, and other job-related factors.

• Eligible for a bonus and new hire equity.
• Pay about 90% of medical, dental, and vision premiums and fund the full deductible on our HSA plan.
• 12 weeks of parental leave at full pay.
• Paid parking or transit.
• 401(k) match.
• Discretionary time off.

Arbor is an equal opportunity employer. We're committed to a hiring process and a workplace free of bias and discrimination, and we welcome candidates of every background.