CNS Histology Specialist - IHC/ISH & Image Analysis

Arbor; Cambridge (MA); On-site; USD 85,000 - 95,000; Full time

Benefits offered by this job

Bonus

Equity

Job summary

Arbor Biotechnologies, a Cambridge, MA-based clinical stage gene editing company, seeks a histology-focused scientist to quantify CNS tissue assays and generate actionable data for program decisions.

You will develop, optimize, and run IHC, IF, and ISH/RNAscope on rodent and non-human primate brain tissue, and analyze results using HALO, QuPath, or ImageJ/Fiji. Strong CNS tissue experience is preferred.

Qualifications

• Bachelor’s degree with 3+ years in industry; or Master’s with 1+ year.
• Experience developing, optimizing, and running IHC/IF/ISH/RNAscope.
• Experience with CNS tissue from rodent models; NHP preferred.
• Quantitative image analysis of CNS histology readouts.
• Experience with gene therapy, gene editing, or CNS programs preferred.

Responsibilities

• Develop, optimize, and run IHC, IF, and ISH/RNAscope on preclinical CNS tissue.
• Process, stain, and image CNS tissue from rodent and non-human primate studies.
• Quantify assay readouts in HALO, QuPath, or ImageJ/Fiji.
• Generate histology data to assess biodistribution, target engagement, pharmacodynamic activity, editing outcomes, and safety.
• Analyze and graph results in GraphPad Prism and summarize them for project scientists.
• Plan histology endpoints and tissue readouts for in vivo studies with the study lead.
• Present results in group meetings and cross-functional study discussions.
• Troubleshoot assays, improve workflows, and keep experimental records and sample tracking accurate.

Skills

IHC

IF

ISH/RNAscope

Image analysis

CNS tissue handling

Education

Bachelor’s degree in biology, neuroscience, pharmacology, or related field

Master’s degree in biology, neuroscience, pharmacology, or related field

Tools

HALO

QuPath

ImageJ/Fiji

Job description

Arbor Biotechnologies, a Cambridge, MA-based clinical stage gene editing company, seeks a histology-focused scientist to quantify CNS tissue assays and generate actionable data for program decisions.

You will develop, optimize, and run IHC, IF, and ISH/RNAscope on rodent and non-human primate brain tissue, and analyze results using HALO, QuPath, or ImageJ/Fiji. Strong CNS tissue experience is preferred.