Senior Bioconjugation Scientist - Process Development Lead

Abzena Inc.

Bristol Township (Bucks County)

On-site

USD 150,000 - 190,000

Full time

6 days ago

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Job summary

Abzena Inc. Bristol is seeking a Bioconjugation Process Development Senior Scientist to lead downstream development for conjugated biotherapeutics, including antibody-drug conjugates and protein-oligonucleotide conjugates.

You will drive scale-up, work on chromatographic purifications, and collaborate with cross-functional teams. The role requires a PhD or MS/BS in biochemical sciences, hands-on experience with AKTA systems, DoE, and cGMP knowledge, with leadership responsibilities for a

Qualifications

PhD or BS/MS in biochemical sciences or bio-engineering with industry experience in biotherapeutic development or bioconjugation.
Experience in preparative purification of biological molecules (antibodies, carrier proteins, viruses, viral vectors, or other biological molecules).
Expertise in normal flow filtrations and tangential flow filtrations (TFF, UF/DF).
Knowledge of strategies for optimization of bioprocesses and experimental design (DoE).
Hands-on experience with preparative chromatography systems (AKTA Pilot, AKTA Ready, AKTA Explorer).
Expertise with quantitative determination of scalable process parameters for filtrations and preparative chromatographic separations.
Knowledge of cGMP manufacturing operations and GxP principles.
Strong knowledge of bioconjugation reactions, techniques and approaches.
Experience with protein bioanalytical techniques (HPLC, LC-MS, UV-spectrophotometry).
Experience with large-scale bioprocess equipment and single-use assemblies.

Responsibilities

Lead bioconjugation downstream process development activities for Abzena Bristol’s operations.
Develop and optimize chromatography, filtration, and conjugation steps for biotherapeutics.
Perform bioanalytical characterization (HPLC, UPLC, LC-MS, MALDI, MALS) of bioconjugates.
Author and review laboratory notebooks, process development reports, protocols, batch records, SOPs.
Mentor and supervise technical team line reports and collaborate with clients and staff.