Senior Associate Scientist, In Vivo Pharmacology, Oncology

Perceptive Inc.; Needham (MA); On-site; USD 53,000 - 98,000; Full time

Job summary

Perceptive Inc. in Needham, MA is seeking a Senior Associate Scientist to support validation and execution of imaging studies in preclinical oncology models, including CDx and PDx platforms with PET/SPECT, CT, MRI and Bioluminescence Imaging.

You will oversee animal care operations, manage procurement, ensure SOP adherence, supervise in vivo tasks, monitor animal health with the AV, and maintain rigorous data records and QC for study completion.

Qualifications

• Bachelor's degree with 5+ years or MS with 3+ years in Biology or Animal Science.
• In vivo preclinical imaging experience and animal model work.
• Ability to mentor staff and manage SOPs/protocols.

Responsibilities

• Aid in management of the Animal Care Facility (ACF).
• Order animals and supplies.
• Maintain sanitization and equipment; follow SOPs.
• Lead in vivo tasks and schedule protocol execution.
• Assess animal health and communicate with Attending Veterinarian.
• Document lab notes and perform data quality control.
• Ensure IACUC compliance.

Skills

Mentor junior staff

Multitasking

Computer proficiency

Written and verbal communication

Weekend availability

Ability to lift 50 pounds

Education

Bachelor's degree in Biology or related field

Master's degree in Biology or related field

Tools

Cayuse IACUC

PET/SPECT/MRI imaging techniques

BSL2 handling

Job description

We are seeking a motivated and skilled Senior Associate Scientist to support validation and execution of our imaging studies using preclinical in vivo oncology- models. This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging. The successful candidate will also provide technical support across a range of in vivo studies including efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry and ex vivo analysis of target tissues of relevance in oncology, xenograft models.

About the Role

This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging.

Responsibilities

• Aid in the management of the Animal Care Facility (ACF)
• Ordering of animals and supplies
• Sanitization and equipment maintenance
• Follow, execute and write laboratory specific SOP’s related to role
• Assess study protocols for experimental details
• Participate in protocol reviews
• Lead projects and schedule necessary In-Vivo tasks
• Meet and determine timelines related to protocol execution
• Assess animal health conditions, communicate with Attending Veterinarian (AV) and provide necessary animal health care
• Learn technical/theoretical applications involved in executing pre-clinical studies
• Cell culture, inoculation, aseptic technique and contamination prevention
• Proficiency monitoring tumor volume, body weight, clinical signs and model-dependent humane endpoints
• Maintain clear and concise laboratory notes
• Perform data quality control and upload relevant documents upon study completion
• Work with IACUC to implement and ensure compliance of animal use protocols

Qualifications

Bachelor +5yrs experience OR MS +3yrs experience in Biology, Animal Science or a related field

Required Skills

• Ability to mentor junior staff
• Multitasking, organizational and time management skills
• Comfort with various computer operating systems and programs
• Strong written and oral communication skills
• Availability to work some weekends as required
• Ability to lift 50 pounds

Preferred Skills

• Ability to perform minor surgical procedures
• Microdissection of tissues (lymph nodes, specific brain sections, etc)
• Experience working with anesthesia
• Experience working with radioactivity
• Experience working with BSL2 animals and samples
• Experience with IACUC/Animal Inventory management system (preferably Cayuse)
• Experience with PET/SPECT/MRI/BLI

The annual base salary range for this role is $52,520- $97,537. This range represents the anticipated initial annual salary and may vary depending on several factors including the candidate’s experience and skills and may be subject to market rate adjustment.