Senior Research Associate, In Vivo Biology

Actinium Pharmaceuticals, Inc.; New York (NY); Sur place; USD 75 000 - 115 000; Plein temps

Résumé du poste

A biotechnology company in New York City is looking for a highly motivated Senior Research Associate to support cancer radiopharmaceutical development. The successful candidate will perform preclinical research, conduct in vivo studies, and collaborate with cross-functional teams. A master's or bachelor's degree in biological sciences with at least 2 years of industry experience is required. The position offers a chance to contribute to innovative cancer treatments in a fast-paced environment.

Qualifications

• Minimum of 2 years experience in biotech or pharmaceutical oncology product development.
• 3-5 years of cancer biology lab research experience in academic settings.
• Experience with handling small animals and in vivo experiments.

Responsabilités

• Perform IACUC approved small animal experiments including in vivo mouse cancer models.
• Administer drugs by various routes; experience in drug formulation is preferred.
• Gather and analyze data from experiments, maintaining documentation.
• Maintain cell culture, aseptic technique, and laboratory notebooks with detailed records.
• Collaborate cross-functionally with Radiochemistry and In Vitro Biology teams.
• Support experimental planning with the Manager, In Vivo Biology and interpret data.

Connaissances

In vivo procedures

Cell culture

Aseptic techniques

Biologic drugs

Communication skills

Organizational skills

Formation

Master's or bachelor's degree in biological sciences

2+ years biotech/pharma industry experience

Outils

MS Office

GraphPad Prism

Description du poste

Actinium Pharmaceuticals develops targeted radiotherapies to improve patient outcomes. Our lead candidate, ATNM-400, is a first‑in‑class Actinium‑225 (Ac‑225) therapy for prostate cancer and lung cancer, showing superior preclinical efficacy and synergy with existing treatments. Actimab‑A, targeting CD33 for AML and other myeloid malignancies, has demonstrated high remission rates in patients and is advancing to pivotal clinical trials, including combination studies with Venetoclax, ASTX‑727, and now PD‑1 inhibitors (KEYTRUDA, OPDIVO) for solid tumors. Additional clinical programs include Iomab‑ACT and Iomab‑B for transplant conditioning. Actinium also pursues preclinical solid tumor programs and holds ~240 patents, including for Ac‑225 production. Building on our expertise and leadership in radiopharmaceuticals, Actinium is rapidly accelerating our investigational research efforts and is looking for talented scientists to join the team.

Job Overview

Actinium is seeking a highly motivated and skilled Senior Research Associate with prior industry experience (2 years) in biologics to actively support the Company’s promising R&D strategy to discover and develop novel cancer radiopharmaceuticals. The qualified individual will have prior experience in an industry (preferred) or academic lab setting, including experience in drug discovery and analysis, designing, and performing preclinical in vivo research studies. This person will independently perform high quality work and collaborate with research associates and laboratory technicians. This position will directly contribute to the R&D team under the guidance of the Manager, In Vivo Biology. The candidate in this role is expected to support preclinical drug discovery and pharmacology studies in rodents and be proficient in oncology animal models, cell culture, and assay development. Experience with non-radioactive drug formulation and handling radioactivity is preferred.

Duties and Responsibilities

• Perform independently planned IACUC approved small animal experiments including in vivo mouse cancer models.
• Administer radioactive and non-radioactive drugs by multiple routes including IV, IP, SC, etc. Experience with non-radioactive drug formulation is preferred.
• Perform independently tumor burden measurements (e.g., using caliper and bioluminescence imaging), body weight measurements, tissue and blood collection and processing samples for ex vivo assays and biodistribution studies.
• Perform planned experiments independently with demonstrated competence in standard mammalian cell culture and aseptic technique.
• Vivarium monitoring and occasional husbandry duties (e.g., cage changing).
• Assist the Manager, In Vivo Biology with experimental planning and execution.
• Gather, interpret and analyze data from performed research experiments.
• Assist with maintaining laboratory equipment (coordinating preventative maintenance and repairs as needed), ordering of reagents and laboratory supplies.
• Maintain laboratory reagent database, including cell lines and antibodies.
• Ensure that safe laboratory practices and IACUC protocols are adhered to including the use and disposal of chemicals and hazardous materials.
• Maintain a detailed electronic laboratory notebook: prepare and maintain detailed records, logs and summary reports of all procedures and results including graphs, data analysis, scientific calculations, and statistical analysis. Experience with MS Office and GraphPad Prism is desirable.
• Collaborate cross‑functionally with colleagues in Radiochemistry and In Vitro Biology to drive translational research.
• Contribute to a culture of scientific excellence by keeping informed on scientific advances and emerging technologies in targeted therapies for oncology.
• Contribute to company culture and team building.

Qualifications

• Master’s or bachelor’s degree in biological sciences with a minimum of 2 years biotech or pharmaceutical company experience in oncology product development. Minimum 3‑5 years of cancer biology lab research experience in academic setting. Industry experience is preferred.
• Demonstrated experience with handling small animals and in vivo procedures.
• Demonstrated experience with cell culture and aseptic techniques.
• Hands‑on experience with isolation and culture of primary human cells or patient‑derived samples is a plus.
• Prior work with biologic drugs and/or radiopharmaceuticals is preferred.
• Experience in immunobiology or radiopharmacology is preferred.Demonstrated critical thinking and troubleshooting is essential.
• Excellent organizational, written and verbal communication skills, detail oriented and should be a self‑starter.
• Ability to handle multiple projects, work in a highly collaborative fast‑paced environment.
• Proactive, creative, and eager to learn and grow.
• Strong interpersonal and communication skills and ability to work in a team setting.

Location

On‑site (NYC)

Seniority level

Associate

Employment type

Full‑time

Job function

Research