Senior Associate Scientist, In Vivo Pharmacology, Oncology

Perceptive Group; Needham (MA); On-site; USD 53,000 - 98,000; Full time

Benefits offered by this job

Health, dental & vision benefits

Paid time off including holidays and.s

401(k) program with life & disability

Job summary

Perceptive Group in Needham, MA seeks a Senior Associate Scientist to support validation and execution of imaging studies using preclinical in vivo oncology models, including PET/SPECT/CT, MRI, and Bioluminescence. The role covers efficacy, biodistribution, PK/Tox analyses and ex vivo tissue assessments.

The candidate will contribute to protocol development, SOPs, and may mentor junior staff while collaborating with cross-disciplinary teams in a fast-paced preclinical environment.

Qualifications

• Bachelor+5yrs experience or MS+3yrs in Biology, Animal Science or related field.
• Experience with in vivo imaging and preclinical oncology models.
• Strong written and oral communication skills.

Responsibilities

• Aid in the management of the Animal Care Facility (ACF).
• Order animals and supplies; sanitize and maintain equipment.
• Follow and write SOPs; participate in protocol reviews.
• Lead in vivo tasks and schedule studies; ensure timelines.
• Assess animal health; communicate with Attending Veterinarian.
• Mentor and train new staff; provide data quality control.

Skills

In vivo pharmacology

PET/SPECT/CT/MRI

IACUC

Team leadership

Data quality control

BSL2 handling

Gamma counting

Animal care

Multitasking

Education

Bachelor degree in Biology/related field

Master's degree in Biology/related field

Tools

Cayuse

PET/SPECT/CT imaging

Imaging systems

Job description

## Senior Associate Scientist, In Vivo Pharmacology, OncologyApplylocations: US MA Needhamtime type: Full timeposted on: Posted Yesterdayjob requisition id: JR104922**About Perceptive**Our mission is to shape the future of clinical research. With decades of experience and the brightest minds in the industry, we help the global biopharmaceutical industry bring new, advanced medical treatments to market, faster.We seek to change the world, and with the support of our teams across the globe, we flourish together. At Perceptive, we are one team. We learn, grow and win together.Are you ready to help change the world?**Apart from job satisfaction, we can offer you:****HEALTH:** - Medical, Dental and Vision benefits for you and your family, including Flexible Spending Accounts (FSA) and Health Savings Accounts (HSAs)**YOURSELF**: - Paid time off policy including holidays and sick time - Internal growth and development programs & trainings**WEALTH:** 401(k) program, life & accident insurance and disability insurance**About the role**We are seeking a motivated and skilled **Senior Associate Scientist** to support validation and execution of our imaging studies using preclinical in vivo oncology- models. This role is central to our preclinical research team and involves building CDx and clinically relevant PDx platforms and hands-on work applying these models with nuclear medicine (PET/SPECT) and computed tomography (CT), MRI, Bioluminescence Imaging. The successful candidate will also provide technical support across a range of in vivo studies including efficacy, biodistribution, pharmacokinetics, tolerability, and dosimetry and ex vivo analysis of target tissues of relevance in oncology, xenograft models.# Key Responsibilities# Essential Functions:Aid in the management of the Animal Care Facility (ACF)* ### Ordering of animals and supplies* ### Sanitization and equipment maintenanceFollow, execute and write laboratory specific SOP’s related to roleAssess study protocols for experimental details* ### Participate in protocol reviews* ### Lead projects and schedule necessary In-Vivo tasks* ### Meet and determine timelines related to protocol executionAssess animal health conditions, communicate with Attending Veterinarian (AV) and provide necessary animal health careLearn technical/theoretical applications involved in executing pre-clinical studies Cell culture, inoculation, aseptic technique and contamination preventionProficiency monitoring tumor volume, body weight, clinical signs and model- dependent humane endpointsMaintain clear and concise laboratory notesPerform data quality control and upload relevant documents upon study completionWork with IACUC to implement and ensure compliance of animal use protocols Preferred functioning set of classical skills:* ### Test article administration IV, IP, SC, IM, PO* ### Perfusion* ### Compound handling* ### Tissue resection* ### Biological sampling proceduresExecution of:* ### Efficacy studies* ### Biodistribution studies* ### Pharmacokinetic studies* ### Toxicokinetic studies* ### Xenograft modelsMentor and train new staffWork with radioactive and BSL2 samples and test articles* ### Gamma counting* ### Sample disposition* ### Proper handling and disposal of associated materialsCommunicate details of your work with scientists and managersProvide husbandry support and routine health checks as neededMay assist under supervision in the operation of PET/SPECT/CT/MRI Other duties as assigned### # Highly Desired Skills* Ability to perform minor surgical procedures* Microdissection of tissues (lymph nodes, specific brain sections, etc)* Experience working with anesthesia* Experience working with radioactivity* Experience working with BSL2 animals and samples* Experience with IACUC/Animal Inventory management system (preferably Cayuse)* Experience with PET/SPECT/MRI/BLIExperience, Education, and Certifications* Bachelor +5yrs experience OR MS +3yrs experience in Biology, Animal Science or a related field* Ability to mentor junior staff* Multitasking, organizational and time management skills* Comfort with various computer operating systems and programs* Strong written and oral communication skills* Availability to work some weekends as required* Ability to lift 50 poundsThis role is based in the Perceptive office/lab located in Needham, MA. The annual base salary range for this role is $52,520- $97,537. This range represents the anticipated initial annual salary and may vary depending on several factors including the candidate’s experience and skills and may be subject to market rate adjustment.