RNA Purification Process Scientist (DoE & High-Throughput)

Bristol Myers Squibb EU Policy; Cambridge (MA); On-site; USD 111,000 - 134,000; Full time

Job summary

Bristol Myers Squibb in Cambridge, MA is hiring a Scientist, Purification for RNA Process Development. The role conducts experiments across early to late development stages to improve RNA purification steps, driving yield, quality, and robustness.

Reporting to a Principal Scientist, you will work hands-on to design robust purification strategies, collaborate with analytical and upstream PD teams, and contribute to tech transfer at GMP sites.

Qualifications

• BS with 6+ years in science disciplines
• MS with 4-6 years in science disciplines
• PhD with 0-2 years in science disciplines
• Expertise in chromatography and filtration
• Solid DoE and multivariate data analysis knowledge
• Experience with process analytics and biophysical characterization

Responsibilities

• Design, execute, and analyze experiments using DoE and statistics
• Define purification process and design space parameters
• Perform high throughput/automated experiments
• Confirm robust process performance across control space
• Collaborate with analytical teams for impurity profiling
• Align with upstream PD to characterize IVT feed stream
• Prepare technical reports and communicate results
• Support tech transfer to GMP manufacturing sites

Skills

DoE

Statistical modeling

RNA purification

HPLC

cGMP knowledge

Education

BS in Bio/Chemical Engineering or related

MS in related field

PhD in related field (0-2 years)

Tools

Chromatography

Filtration (TFF/UF-DF)

Analytical techniques (HPLC, CE, gels)

Job description

Bristol Myers Squibb in Cambridge, MA is hiring a Scientist, Purification for RNA Process Development. The role conducts experiments across early to late development stages to improve RNA purification steps, driving yield, quality, and robustness.

Reporting to a Principal Scientist, you will work hands-on to design robust purification strategies, collaborate with analytical and upstream PD teams, and contribute to tech transfer at GMP sites.