Scientist, Purification, RNA Process Development

Bristol-Myers Squibb Co; Cambridge (MA); On-site; USD 111,000 - 134,000; Full time

Benefits offered by this job

Flexible Time Off

11 paid holidays

Vacation time 160 hours (new hires)

Volunteer days

Summer hours

Leaves of absence

Global Shutdown

Job summary

Bristol Myers Squibb in Cambridge, MA, is seeking a Scientist for RNA purification process development to design and optimize purification steps for RNA drug substances across development stages. You will execute experiments, build design spaces, and work with upstream/downstream teams to improve yield and purity.

The role emphasizes collaboration, data-rich experimentation, and cross-functional partnerships within a flexible work model.

Qualifications

• BS with 6+ years of science experience.
• MS with 4-6 years of science experience.
• PhD with 0-2 years of science experience.
• Expertise in chromatography, filtration and unit operations.
• Knowledge of DoE and multivariate data analysis.
• Regulatory knowledge (cGMP, ICH) relevant to clinical manufacturing.
• Experience supporting GMP manufacturing and tech transfer.

Responsibilities

• Design, execute, and analyze experiments for existing and novel process modes using DoE and statistical modeling.
• Define the RNA drug substance purification process, the critical parameters, and the design space.
• Experiment using high throughput/automated or data rich experimental setups.
• Design experiments to confirm robust process performance across the control space.
• Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles.
• Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity.
• Prepare technical reports, and communicate findings internally and externally as appropriate.
• Participate in tech transfer activities to GMP manufacturing sites for RNA programs.

Skills

DoE and statistics

Chromatography

Filtration

Multivariate data analysis

Process analytics

RNA chemistry knowledge

cGMP regulatory knowledge

Technical support for clinicalmanufact

Education

BS in Bio/Chemical Engineering or related field

MS in related field

PhD in related field

Tools

HPLC

CE

Gel electrophoresis

Job description

At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it.

Position Summary

The RNA Purification Process Development function plays a central role in designing efficient, robust, and scalable manufacturing processes. By combining deep scientific expertise with enabling technologies and strong cross‑functional partnerships, RNA Process Development delivers transformative innovation across the pipeline. The Scientist executes robust experiments for drug substance programs spanning early‑to‑late‑stage development across circular and linear mRNA modalities. Reporting to the Principal Scientist, this role encompasses hands‑on contributions, addressing critical challenges by driving sound experimental execution and manufacturing support. The candidate should be driven by developing and characterizing chromatography and filtration steps for improving the yield, quality and robustness of purification process steps.

Key Responsibilities

• Design, execute, and analyze experiments for existing and novel process modes using DoE and statistical modeling
• Define the RNA drug substance purification process, the critical parameters, and the design space
• Experiment using high throughput/automated or data rich experimental setups
• Design experiments to confirm robust process performance across the control space
• Collaborate with analytical teams to enable deeper characterization of RNA properties and impurity profiles
• Collaborate closely with upstream PD to characterize IVT feed stream to maximize RNA yield and purity
• Prepare technical reports, and communicate findings internally and externally as appropriate
• Participate in tech transfer activities to GMP manufacturing sites for RNA programs

Qualifications & Experience

• Degree in Bio/Chemical Engineering, Bio/Chemistry, or related field BS with 6+ years’ experience in science related disciplines
• MS with 4-6 years’ experience in science related disciplines
• PhD with 0 - 2 years’ experience in science related disciplines
• Expertise in chromatography, filtration (TFF/UF-DF), and innovative separation unit operations
• Solid knowledge foundation of statistical design of experiments (DoE) and analysis of multivariate data
• Experience with performing process analytics and biophysical characterization techniques such as HPLC, CE, & gel electrophoresis
• Knowledge of cGMP, ICH, regulatory guidelines and QbD principles as they apply to risk management and clinical manufacturing
• Demonstrated background of providing technical support for clinical manufacturing processes, including support of process investigations, and implementation of proactive process modifications
• Knowledge of advanced mathematics, nucleic acid chemistry, lipid chemistry, and biology is a plus
• Knowledge of establishing and qualifying scale down models and mechanistic models for process characterization is a plus

Compensation Overview:

Cambridge - MA - US: $110,810 - $134,281 The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

• Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).
• U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.
• Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.
• Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs.
• Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day. U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

How We Work

Where you work matters – because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. Learn more at https://careers.bms.com/ways-of-working.

Supporting People with Disabilities

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [e-mail]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area. For roles based in Los Angeles County only: If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection. Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

We’re creating innovative medicines for patients fighting serious diseases. We’re also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference.