gRNA Process Development Scientist: Scale-Up & Purification

Eurofins PSS Insourcing Solutions; Boston (MA); On-site; USD 44,000 - 56,000; Full time

Benefits offered by this job

Medical, dental, and vision coverage

Life and disability insurance

401(k) with company match

Paid vacation and holidays

Yearly bonus opportunities

Job summary

Eurofins PSS Insourcing Solutions in Boston is seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will synthesize, purify, and characterize gRNAs to develop drug substance manufacturing processes and controls for programs in clinical development.

The role requires hands-on experience with oligonucleotide synthesis and purification, routine analytics (HPLC, UV-Vis), bench-scale to transfer manufacturing processes, and strong

Qualifications

• B.S./M.S. in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience.
• Experience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus)
• Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangential Flow Filtration (TFF) is required.
• Ability to follow established SOPs for routine analytical support.
• Experience with good documentation practices and electronic lab notebooks such as Benchling.
• Unwavering commitment to safety protocols and procedures.

Responsibilities

• Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.
• Execute routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.
• Compile and present data to team members and key stakeholders.
• Maintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.
• Uphold lab safety to the highest level of standards.

Skills

Oligonucleotide synthesis

Analytical skills

Laboratory safety

Documentation skills

Team collaboration

Problem solving

Education

B.S./M.S. in chemistry/biochemistry/related field

2+ years lab experience

Tools

Akta chromatography systems

Agilent UHPLC

NanoDrop

Gel electrophoresis

Tangential Flow Filtration (TFF)

Job description

Eurofins PSS Insourcing Solutions in Boston is seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will synthesize, purify, and characterize gRNAs to develop drug substance manufacturing processes and controls for programs in clinical development.

The role requires hands-on experience with oligonucleotide synthesis and purification, routine analytics (HPLC, UV-Vis), bench-scale to transfer manufacturing processes, and strong