gRNA Process Development Scientist: Scale-Up & Purification

Eurofins USA PSS Insourcing Solutions; Boston (MA); On-site; USD 44,000 - 56,000; Full time

Benefits offered by this job

Comprehensive medical coverage

Dental and vision options

401(k) with company match

Paid vacation and holidays

Yearly bonus & merit-based increases

Job summary

Eurofins USA PSS Insourcing Solutions is seeking a process development scientist to join the gRNA process development team in Boston. You will synthesize, purify, and characterize gRNAs to advance drug substance manufacturing processes.

Responsibilities include carrying out solid-phase synthesis, purification, routine analytics (HPLC/UV-Vis), preparing buffers, compiling data, and maintaining meticulous notebooks in a fast-paced, safety-conscious lab.

Qualifications

• B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experience.
• Experience with oligonucleotide synthesis and purification equipment; gRNA or longmer synthesis/purification is a plus.
• Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.
• Experience with Tangential Flow Filtration (TFF) is required.
• Ability to follow SOPs and maintain electronic lab notebooks (Benchling).
• Commitment to safety, detail orientation, and strong time-management.

Responsibilities

• Execute solid-phase synthesis and purification for process development, scale-up, and transfer.
• Perform routine analytics including HPLC and UV-Vis.
• Prepare buffers, reagents, and stock solutions per SOPs.
• Compile and present data to team members and stakeholders.
• Maintain an updated lab notebook, order materials, and support equipment troubleshooting.
• Uphold lab safety to the highest standards.

Skills

Oligonucleotide synthesis

Analytical instrumentation

Bench notebook documentation

Safety protocols

Data presentation

Communication

Problem solving

Education

B.S./M.S. in chemistry/biochemistry/chemical engineering

Tools

Akta chromatography systems

Agilent HPLC/UHPLC

NanoDrop

Tangential Flow Filtration (TFF)

Job description

Eurofins USA PSS Insourcing Solutions is seeking a process development scientist to join the gRNA process development team in Boston. You will synthesize, purify, and characterize gRNAs to advance drug substance manufacturing processes.

Responsibilities include carrying out solid-phase synthesis, purification, routine analytics (HPLC/UV-Vis), preparing buffers, compiling data, and maintaining meticulous notebooks in a fast-paced, safety-conscious lab.