Research Fellow

Massachusetts General Physicians Organization, Inc.; Boston (MA); Sur place; USD 70 000 - 72 000; Plein temps

Résumé du poste

The Vaccine and Immunotherapy Center at Massachusetts General Hospital offers a two-year private foundation postdoctoral fellowship focused on translational medical research for type I diabetes. The fellow will study gene- and cell-therapy approaches and will work with multidisciplinary teams across immunology, transplantation, and data analysis.

Responsibilities include hands-on experimental work, collaboration with external partners, and advancing preclinical work toward clinical stages.

Qualifications

• PhD in Biology, Immunology, Biochemistry, or related field.
• Strong publication record and ability to write funding proposals.
• Understanding/knowledge of gene delivery systems, transplant tolerance and transplant biology.
• Passionate and curious to advance therapies from preclinical to clinical stage.
• Strong interpersonal, organizational and communication skills.

Responsabilités

• Conduct experiments and analyze data in immunomodulatory and cell-gene therapies for type I diabetes.
• Collaborate with outside academic and industry partners.
• Design novel translational studies using mouse models of disease.

Connaissances

Strong publication record

Interpersonal skills

Data analysis

Experimental design

Communication skills

Formation

PhD in Biology/Immunology/Biochemistry or related field

Outils

qPCR

Western blot

ELISPOT

Flow cytometry

Non-viral gene delivery

AAV-based approaches

Description du poste

Site

Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

A two-year, private foundation postdoctoral fellowship is available at the Vaccine and Immunotherapy Center, Massachusetts General Hospital. The fellowship would focus on translational medical research aimed at developing novel therapeutic approaches for type 1 diabetes, with a particular emphasis on gene and cell therapies, immunomodulation and transplant biology.

About the Vaccine and Immunotherapy Center

The mission of the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital is to accelerate the development of novel, broadly applicable vaccines and immunotherapies aimed at eradicating cancer, infectious diseases, and type I diabetes. VIC accomplishes this by: bringing together scientists, physicians and business leaders experienced in transforming promising laboratory discoveries into therapies providing improved patient treatment. Funding selected projects and providing project management, technological transfer and practical assistance to ensure project success. Identifying high yield translational medical research with a 2-3 year horizon for implementation in patients.

Key Tasks and Responsibilities

The individual will work in a creative and multidisciplinary team with other scientists on novel designs for immunomodulatory and cell-gene therapies for type I diabetes. Studies will involve therapeutic studies in established mouse models of disease and application of immunologic tools to define key mechanisms of action in graft immune protection. The fellow will be directly responsible for the conduct of experiments and will work with a team in analysis of data. Projects will involve work with outside academic and industry collaborators.

Essential Requirements

• PhD in Biology, Immunology, Biochemistry, or a related field
• Strong publication record and demonstrated ability to write funding proposals
• Understanding/knowledge of gene delivery systems, transplant tolerance and transplant biology
• Passionate and curious to advance therapies from preclinical to clinical stage
• Strong interpersonal, organizational and communication skills

Professional Skills & Experience

• Careful documentation of research plan, execution and data collection
• Experimental design, animal model development and data analysis
• Experience with animal handling (IV, IP and SQ injections), tissue processing and primary cell culture
• Experience with functional assays such as cytotoxicity assays, ELISPOT, ELISA and cytokine release assays
• Experience in working with pancreatic islet cells, T cells, other immune cells, immunological techniques, multicolor flow cytometry is desirable
• Experience in vivo gene delivery strategies, particularly using non-viral gene delivery platforms (e.g., lipid-based carriers and LNPs), as well as AAV-based approaches and imaging systems are a plus
• Experience with basic molecular biology techniques, including qPCR and Western blot

Additional Job Details (if applicable)

• The compensation range for this role is between $70,000-$71,500. Final compensation will be determined based on years of relevant experience, skills, and internal equity.

Remote

• Onsite

Work Location

• 149 Thirteenth Street Building
• 149

EEO Statement

1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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