Research Fellow Center for Genomic Medicine

Massachusetts General Physicians Organization, Inc.; Boston (MA); Presencial; USD 70.000 - 72.000; Jornada completa

Descripción de la vacante

The Musolino Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, seeks a highly motivated post-doctoral Research Fellow. The position focuses on gene therapy innovations for rare vascular conditions and collaborates with a multidisciplinary team in a stimulating environment.

The candidate should have experience or a strong capacity to learn mammalian cell culture, CRISPR/Cas9 genome editing, and diverse molecular genetics techniques, with

Formación

• Ph.D. in a relevant biological field with first (or co-first) author publications.
• Experience or high capacity to learn mammalian cell culture and genome editing.
• Experience with molecular genomics techniques (PCR, qPCR, RNAseq).
• Ability to supervise and train staff, and to work both independently and in a team.

Responsabilidades

• Perform CRISPR-based genome editing using established protocols.
• Design, execute, and interpret research experiments in genomic medicine.
• Maintain detailed laboratory records and organize data for publications.
• Contribute to research presentations at meetings and collaboratively train staff.

Conocimientos

CRISPR genome editing

Mammalian cell culture

Molecular genomics techniques

RNAseq / RNA sequencing

Educación

Ph.D. in a biological field

Herramientas

PCR

DNA/RNA extraction

Single-cell RNAseq (scRNAseq) techniques

Descripción del empleo

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

The Musolino Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral Research Fellow candidates. At the Musolino laboratory we are dedicated to the development and application of innovations in gene therapy technologies for rare vascular conditions. The candidate will be expected to have experience, or high capacity to learn, mammalian cell culture, CRISPR/Cas9 genome editing, murine modeling, and various molecular genetic techniques. The team will include the Principal Investigators and other faculty, research scientists, postdoctoral fellows, and research technicians and technologists. In this position we are seeking a Research Fellow with the enthusiasm to develop projects that will contribute to diverse and highly collaborative research programs. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and at the Harvard Medical School.

PRINCIPAL DUTIES AND RESPONSIBILITIES

• Perform CRISPR-based genome editing using established protocols
• Perform molecular genomics procedures as needed (i.e., DNA/RNA extraction, library production, RNAseq, sample archiving, tissue culture, etc.)
• Design, execute, and interpret research experiments
• Learn any number of molecular genomics techniques including single-cell RNAseq (scRNAseq), ATACseq, ChIPseq, HiC, and other methods
• Routinely check medium, reagents, and plasticwares for cell culture experiments
• Maintain mouse colonies and process murine tissues for phenotypic evaluation
• Perform noninvasive and invasive hemodynamic assessments of mouse models of human disease
• Maintain laboratory notebook
• Independently follow detailed protocols while working closely with a wide range of lab members (i.e., graduate students, postdocs, technicians, staff scientists)
• Assist in training new Research Technicians and Fellows
• Responsible for troubleshooting problems and instructing others in highly specialized techniques.
• Investigate, create, and develop new methods and technologies for research advancements.
• Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports.
• Contribute to research presentations at local, national, and international meetings.
• Oversight of laboratory technicians participating on the projects, including training them, and assisting them with experimental design and implementation.
• Compose and present sections of research reports.
• Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation.

The Research Fellow will be situated in the MGH under the guidance and mentorship of Dr. Patricia Musolino.

Qualifications SKILLS & COMPETENCIES REQUIRED

The ideal candidate should have received (or expect to receive soon) a Ph.D. in a relevant biological field. First (or co-first) author of one or more peer-reviewed scientific publications Excellent English verbal and written communication skills Able to work both independently and in a team Experience with delivery of genomic therapies such as LNPs and/or genome editing - required. Experience in molecular genomic techniques (i.e., PCR, qPCR, RNAseq, gel electrophoresis) Experience in mammalian cell culture - required Interest in learning and troubleshooting new molecular biology techniques Familiarity with animal modeling of disease - required Excellent organizational and communication skills Sound interpersonal skills and the ability to supervise and train staff effectively. Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab. Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.

EDUCATION

Minimum Required: Doctoral Degree Preferred: Doctoral Degree

EXPERIENCE

Required: Recent PhD graduate, 3+ years of experience in a research-related field required

SUPERVISORY RESPONSIBILITY (authority to hire, promote, or terminate)

May oversee research Assistants, Technicians, Technologists, and Students. No authority to hire/promote/terminate

WORKING CONDITIONS

Work will be performed in the Simches Research Building on the Massachusetts General Hospital main campus, in Boston, MA.

Additional Job Details (if applicable)

The salary for this position ranges from $70,000 to $71,750.

Remote Type Onsite Work Location 185 Cambridge Street

EEO Statement

1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.

About Us

Combat disease. Hold a hand. Help people. Impact the world. Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Are you ready? Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.