Research Fellow Center for Genomic Medicine

1300 Massachusetts General Physicians Organization, Inc.; Boston (MA); On-site; USD 70,000 - 72,000; Full time

Job summary

The Musolino Laboratory at Massachusetts General Hospital, within the Center for Genomic Medicine, seeks a highly motivated post-doctoral Research Fellow. The role focuses on the development and application of gene therapy technologies for rare vascular diseases and will involve CRISPR/Cas9 genome editing and mammalian cell culture.

The successful candidate will work in a collaborative team with Principal Investigators, postdocs, technicians, and students, contribute to experiments, data

Qualifications

• The ideal candidate must have or be about to complete a Ph.D. in a relevant biological field.
• Experience with CRISPR/Cas9 genome editing and mammalian cell culture is required.
• Strong publication record and ability to work independently and in a team.
• Experience with genomic therapies and molecular genomic techniques is preferred.

Responsibilities

• Perform CRISPR-based genome editing using established protocols.
• Conduct molecular genomics procedures (DNA/RNA extraction, RNAseq, etc.).
• Design, execute, and interpret research experiments.
• Maintain laboratory notebooks and assist training of staff.
• Prepare written data reports and contribute to manuscripts.

Skills

Ph.D. in biology

Excellent English communication

Independent and team player

Genomic therapies experience

Molecular genomic techniques

Mammalian cell culture

Animal modeling experience

Willingness to learn new techniques

Education

Doctoral Degree

Job description

Job Summary

Site: Massachusetts General Physicians Organization, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

The Musolino Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral Research Fellow candidates. At the Musolino laboratory we are dedicated to the development and application of innovations in gene therapy technologies for rare vascular conditions. The candidate will be expected to have experience, or high capacity to learn, mammalian cell culture, CRISPR/Cas9 genome editing, murine modeling, and various molecular genetic techniques. The team will include the Principal Investigators and other faculty, research scientists, postdoctoral fellows, and research technicians and technologists. In this position we are seeking a Research Fellow with the enthusiasm to develop projects that will contribute to diverse and highly collaborative research programs. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and at the Harvard Medical School.

Principal Duties and Responsibilities:

• Perform CRISPR-based genome editing using established protocols
• Perform molecular genomics procedures as needed (i.e., DNA/RNA extraction, library production, RNAseq, sample archiving, tissue culture, etc.)
• Design, execute, and interpret research experiments
• Learn any number of molecular genomics techniques including single-cell RNAseq (scRNAseq), ATACseq, ChIPseq, HiC, and other methods
• Routinely check medium, reagents, and plasticwares for cell culture experiments
• Maintain mouse colonies and process murine tissues for phenotypic evaluation
• Perform noninvasive and invasive hemodynamic assessments of mouse models of human disease
• Maintain laboratory notebook
• Independently follow detailed protocols while working closely with a wide range of lab members (i.e., graduate students, postdocs, technicians, staff scientists)
• Assist in training new Research Technicians and Fellows
• Responsible for troubleshooting problems and instructing others in highly specialized techniques.
• Investigate, create, and develop new methods and technologies for research advancements.
• Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports.
• Contribute to research presentations at local, national, and international meetings.
• Oversight of laboratory technicians participating on the projects, including training them, and assisting them with experimental design and implementation.
• Compose and present sections of research reports.
• Organize and/or draft material for the preparation of research papers, manuscripts, or other documents for publication and/or presentation.

Qualifications / Skills & Competencies Required:

• The ideal candidate should have received (or expect to receive soon) a Ph.D. in a relevant biological field.
• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent English verbal and written communication skills
• Able to work both independently and in a team
• Experience with delivery of genomic therapies such as LNPs and/or genome editing - required.
• Experience in molecular genomic techniques (i.e., PCR, qPCR, RNAseq, gel electrophoresis)
• Experience in mammalian cell culture - required
• Interest in learning and troubleshooting new molecular biology techniques
• Familiarity with animal modeling of disease - required
• Excellent organizational and communication skills
• Sound interpersonal skills and the ability to supervise and train staff effectively.
• Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
• Ability to function with speed, precision, and an understanding of theory behind protocols and experiments.

Education

Minimum Required: Doctoral Degree
Preferred: Doctoral Degree

Experience

Required: Recent PhD graduate, 3+ years of experience in a research-related field required

Supervisory Responsibility

May oversee research Assistants, Technicians, Technologists, and Students. No authority to hire/promote/terminate

Working Conditions

Work will be performed in the Simches Research Building on the Massachusetts General Hospital main campus, in Boston, MA.

The salary for this position ranges from $70,000 to $71,750.

EEO Statement

1300 Massachusetts General Physicians Organization, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the RehabilitationActof1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

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