Remote Senior Clinical Trial Manager — Global Contract

Regulatory Jobs; Boston (MA); Hybrid; USD 96,000 - 138,000; Full time

Benefits offered by this job

Medical, dental, vision plans

401(k) retirement plan

Wellness programs

Discounts

Job summary

Centessa Pharmaceuticals is seeking a Senior Clinical Trial Manager (contract-to-hire) to lead global clinical studies from startup through closeout. This remote US-based role requires oversight of timelines, budgets, vendors, and regulatory readiness.

The position is temporary with potential to convert to permanent, involving cross-functional leadership, risk management, and study delivery across multiple regions.

Qualifications

• Bachelor's degree in a scientific, health-related, or equivalent discipline.
• 8+ years of clinical research experience, including 5+ years in clinical trial management.
• 2+ years of managing Phase 1 Healthy Volunteer studies.
• Experience leading Phase 1, and global Phase II/III trials.

Responsibilities

• Lead global clinical trials from startup through closeout.
• Serve as the primary operational lead for assigned studies and drive cross-functional alignment.
• Develop and manage study timelines, budgets, enrollment forecasts, risk mitigation and KPIs.
• Oversee CROs and external vendors to ensure delivery against scope, quality, timelines and budget.
• Drive key milestones: site activation, enrollment, database lock, closeout.
• Ensure TMF quality and inspection readiness throughout the study lifecycle.
• Support regulatory submissions, audits, inspections, and health authority interactions.

Skills

Clinical research

Trial management

Phase I studies

CRO management

Regulatory inspections

Neuroscience/CNS

Pharmacology packages

Study leadership

Education

Bachelor's degree in a scientific field

Job description

Centessa Pharmaceuticals is seeking a Senior Clinical Trial Manager (contract-to-hire) to lead global clinical studies from startup through closeout. This remote US-based role requires oversight of timelines, budgets, vendors, and regulatory readiness.

The position is temporary with potential to convert to permanent, involving cross-functional leadership, risk management, and study delivery across multiple regions.