Remote CNS Clinical Trial Manager (Contract-to-Hire)

Regulatory Jobs; Boston (MA); Hybrid; USD 90,000 - 124,000; Full time

Benefits offered by this job

Medical plans

Dental and vision coverage after 30+?0

401(k)

Wellness programs

Other discounts

Job summary

Centessa Pharmaceuticals seeks a Contract to Hire Clinical Trial Manager to lead mid‑ to late‑stage global CNS studies from study start‑up through close‑out. This remote US‑based role involves day‑to‑day trial management, coordinating cross‑functional teams, and overseeing CROs to ensure studies are delivered on time, within budget and in compliance with regulatory standards.

You will monitor study progress with dashboards, manage risks, and contribute to study documentation for health

Qualifications

• Bachelor's degree in a scientific or health-related field is required.
• 5+ years of clinical trial management experience in industry sponsor environments.
• Experience managing CNS trials and global studies.
• Knowledge of ICH/GCP and global regulatory requirements.
• Strong project management skills including timelines, budgets, and risk.
• Excellent communication and collaboration across teams.

Responsibilities

• Plan and lead mid-to-late-stage CNS trials from start-up to close-out.
• Coordinate cross-functional partners to ensure efficient trial execution.
• Oversee CROs and vendors, monitor scope, timelines, and quality.
• Drive milestones like site activation, enrollment, data cleaning, and database lock.
• Review CRO/vendor plans for protocol alignment and quality.
• Maintain dashboards and financial tracking; provide status updates.
• Identify and mitigate operational risks affecting timelines or budgets.
• Ensure TMF setup, maintenance, and audit readiness for CNS studies.
• Support regulatory deliverables and process improvements.

Skills

Communication skills

Collaboration

Problem solving

Project management

Cross-functional leadership

Timeline management

Stakeholder management

Education

Bachelor’s degree in a scientific or health-related discipline

CNS experience

PMP or similar training

Job description

Centessa Pharmaceuticals seeks a Contract to Hire Clinical Trial Manager to lead mid‑ to late‑stage global CNS studies from study start‑up through close‑out. This remote US‑based role involves day‑to‑day trial management, coordinating cross‑functional teams, and overseeing CROs to ensure studies are delivered on time, within budget and in compliance with regulatory standards.

You will monitor study progress with dashboards, manage risks, and contribute to study documentation for health